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Biovision | GLPG-1690 | B1850

GLPG-1690 is a selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).GLPG-1690 is a selective autotaxin inhibitor with potential application in idiopathic...

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Biovision | Globosuxanthone A | B2130

Globosuxanthone A is a dihydroxyxanthenone isolated from Chaetomium globosum. It displays activity against several solid tumor cell lines, NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, and DU-145...

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Biovision | GKT-137831 | 9444

GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100–150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a...

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Biovision | GJ-103 Sodium salt | B1842

GJ103 sodium salt is an active, water-soluble analog of the read-through compound GJ072. Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy...

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Biovision | Givinostat hydrochloride | B2081

Givinostat is a potent hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II...

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Biovision | Ginkgolic acid C15:1 | 9523

Ginkgolic acid is a naturally occurring compound. It inhibits protein SUMOylation both in vitro and in vivo without affecting in vivo ubiquitination. Binding assays with a fluorescently labeled probe...

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Biovision | Gibberellic acid | B2234

Gibberellic acid (GA) is a tetracyclic di-terpenoid and a plant hormone that stimulates plant growth and development. It stimulates seed germination, triggers transitions from meristem to shoot...

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Biovision | GFT505 | B1030

GFT505 (Elafibranor) is a novel liver-targeted peroxisome proliferator-activated receptor alpha/delta (PPARα/δ) agonist. Displays anti-diabetic effects in db/db mice.GFT505 (Elafibranor) is a novel...

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Biovision | Geodin | 9685

Geodin is a Plasmigen activator inhibitor (PAI-1) inhibitor and Glucose uptake stimulator.Geodin is a Plasmigen activator inhibitor (PAI-1) inhibitor and Glucose uptake stimulator.Biovision | 9685 |...

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Biovision | Gentamicin sulfate | B1270

Gentamicin sulfate, a broad-spectrum aminoglycoside antibiotic, used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. Gentamicin causes codon...

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Biovision | Gemcitabine Hydrochloride | 1759

A nucleoside analog of deoxycytidine used in chemotherapy to treat various types of cancer. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and...

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Biovision | GDC0994 | B1629

GDC-0994 is highly selective inhibitor of extracellular signal-regulated kinase (ERK), ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively.GDC-0994 is highly selective...

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Biovision | GDC-0980 | 2668

GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). It inhibits PI3Kα/β/δ/γ with IC₅₀ values of 5 nM/27 nM/7 nM/14 nM, respectively and mTOR...

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Biovision | GDC-0941 Dimethanesulfonate | 9618

GDC-0941 is a potent, selective, inhibitor of pan-class I PI3 kinase (PI3K), with IC₅₀ values of 3, 33, 3, 75, 1230 and 580 nM for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Displays...

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Biovision | GDC-0941 | 1623

GDC-0941 is a potent inhibitor of p110α and p110δ (IC₅₀ = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger...

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Biovision | GDC-0917 | B1918

GDC-0917 (CUDC-427) is a second mitochondrial activator of caspases (Smac) mimetic, a small molecule inhibitor, that mimics Smac, an endogenous antagonist of IAP proteins. GDC-0917 binds to the Smac...

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Biovision | GDC0879 | B1340

A novel, potent, and selective inhibitor of B-Raf with an IC50 value of 0.13 nMA novel, potent, and selective inhibitor of B-Raf with an IC50 value of 0.13 nMBiovision | B1340 | GDC0879...

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Biovision | GDC-0853 | B2074

GDC-0853 is a potent and selective, Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. GDC-0853 suppresses B cell- and myeloid cell-mediated components of disease and...

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Biovision | GDC-0449 | 1890

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes...

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Biovision | GDC-0068 | 2667

GDC-0068 is a potent, ATP-competitive, pan-Akt inhibitor with IC₅₀s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Displays selectivity over more than other 200 screened kinases. Potential...

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Biovision | GDC-0032 | 9573

GDC-0032 is a potent, and selective inhibitor of Class I PI3-K α, δ, and γ isoforms, with 30-fold less inhibition of the PI3K β isoform relative to the PI3K α isoform. This next generation PI3-K...

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Biovision | GBR-12935 | B1998

GBR-12935 is a potent and selective dopamine reuptake inhibitor.GBR-12935 is a potent and selective dopamine reuptake inhibitor.Biovision | B1998 | GBR-12935 DataSheetAlternate Name/Synonyms: 1-(2...

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Biovision | Gardiquimod | 2002

A selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-κB in HEK 293 cells expressing TLR7. Activates TLR8 only at high concentrations (3µg/ml). Gardiquimod...

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Biovision | GANT61 | 1892

Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC₅₀ = 5 µM). GANT61 has also been shown to inhibit the in vitro...

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Biovision | GANT58 | 1812

Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in...

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Biovision | Ganetespib (STA-9090) | 9459

Ganetespib (STA-9090) is a non-Geldanamycin, selective Hsp90 inhibitor that displays antineoplastic activity. downregulates VEGFR, c-MET, HER2, IGF-IR, EGFR, and other Hsp90 client proteins involved...

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Biovision | Galloflavin | 2672

Galloflavin is a lactate dehydrogenase (LDH) inhibitor inhibiting both LDH-A and LDH-B isoforms of the enzyme with Ki values of 5.46 a µM and 15.06 µM, respectively. It blocks the proliferation of...

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Biovision | Galiellactone | 2623

Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC₅₀ = 0.25-0.5 μM). The selectivity of this compound is achieved by its ability to...

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Biovision | Fusidic acid | B2392

Fusidic Acid is a bacteriostatic antibiotic derived from the fungus Fusidium coccineum that acts as a bacterial protein synthesis inhibitor by preventing the turnover of elongation factor G (EF-G)...

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Biovision | Fusicoccin | B1625

Fusicoccin is a toxin originally extracted from Fusicoccum amygdali DelFusicoccin is a toxin originally extracted from Fusicoccum amygdali DelBiovision | B1625 | Fusicoccin DataSheetAlternate...

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Biovision | FURA-5F/AM | 9551

FURA-5F/AM is a fluorescent cell membrane-permeant form of FURA-2 (Cat. No. 2243) that can be loaded into the cell where it is hydrolysed by cytosolic esterases and trapped as the active chelator. ...

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Biovision | FURA-4F/AM | 9550

Fura-4F AM is a fluorescent intracellular ratiometric calcium indicator analog of FURA-2 (Cat. No. 2243) for detection of higher Ca²⁺ concentrations. lmax: 370± 3 nm (EtOAc); lem: 475± 4 nm (EtOAc)...

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Biovision | Fucoxanthine | B2072

Fucoxanthin is a natural pigment found in microalgae, especially diatoms and Chrysophyta. Recently, it has been shown to have antioxidant, anti-inflammatory, anti-tumor, and anti-obesity activity in...

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Biovision | FTI-277 hydrochloride | 2874

FTI-277 is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM). It potently inhibits (IC₅₀ = 100 nM) H-Ras, but not the geranylgeranylated Rap1A processing in whole cells...

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Biovision | FR180204 | B1683

FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1...

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Biovision | FPH2(BRD-9424） | B2267

FPH2 (BRD-9424) is a potent promoter of differentiation of iPS-derived hepatocytes. FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes...

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Biovision | Fosinopril sodium | B2137

Fosinopril is the ester prodrug of fosinoprilat, an angiotensin converting enzyme (ACE) inhibitor. In vivo, fosinopril is rapidly hydrolyzed to fosinoprilat in the gastrointestinal mucosa and liver...

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Biovision | Formestane | B2041

Formestane is a steroidal aromatase inhibitor. It binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral...

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Biovision | FMK Negative Control | 1122

The reagent can be used as a negative control for FMK-labeled caspase inhibitors.Z-FA-FMK is a useul negative control for FMK-labeled caspase inhibitors.Biovision | 1122 | FMK Negative Control...

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Biovision | Fluvastatin sodium | B2367

Fluvastatin sodium is a potent and selective HMG-CoA reductase inhibitor. It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits increases in serum...

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Biovision | Fluorescent sensor, ANQ | 9695

ANQ is a highly sensitive, selective and turn-on sensor for Lead (II) and Aluminium (III). The detection limit for Pb²⁺ is 2.08 x 10-9 mol/L-1). Useful for detection of intracellular Pb²⁺/Al³⁺ within...

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Biovision | Fludarabine Phosphate | 1763

A chemotherapy drug used in the treatment of hematological malignancies. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine...

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Biovision | FK-866 | 1914

Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an...

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Biovision | FK-506 | 1563

A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12),...

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Biovision | FIPI (free base) | B2372

FIPI is a potent and selective phospholipase D (PLD) inhibitor. FIPI inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC₅₀ = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell...

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Biovision | Fingolimod (FTY-720A, FTY720) | 1618

FTY720 can be phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). IC₅₀ of (S)- and (R)-...

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Biovision | Filipin III | 2744

Filipin III is a polyene macrolide antibiotic isolated from Streptomyces filipinensis. It may be used in a double staining procedure for the detection of lipoproteins. Binds specifically to...

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Biovision | FH1 (BRD-K4477) | 2732

FH1 is a small molecule that can enhance the functions of cultured hepatocytes. It enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes and promotes the maturation of...

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Biovision | FG-4592 | 9681

FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase, potentially useful for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription...

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Biovision | Fexaramate | 9560

Fexaramate is a potent, selective, non-steroidal, farnesoid X receptor (FXR) agonist.Fexaramate is a potent, selective, non-steroidal, farnesoid X receptor (FXR) agonist.Biovision | 9560 | Fexaramate...

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Biovision | FeTPPS | 2065

A peroxynitrite decomposition catalyst. An iron porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro thus serving as a decomposition catalyst and a...

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Biovision | Fatostatin | 2035

Cell-permeable. Blocks adipogenesis by inhibiting the activation of SREBPs (Sterol Regulatory Binding Proteins). Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein...

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