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Biovision

  • IKK16

    Biovision | IKK16 | B1087

    IKK-16 is a potent and selective inhibitor of IκB kinase (IKK) with IC₅₀ values from 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. It is effective in cells and in animals and has...

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  • IDO1 Inhibitor I

    Biovision | IDO1 Inhibitor I | 2745

    IDO1 Inhibitor I is a potent IDO1 inhibitor that displays IC₅₀ values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan...

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  • IDE-1

    Biovision | IDE-1 | 2193

    Cell-permeable. Directs differentiation of embryonic stem cells (ESCs) into the endodermal lineage (EC₅₀ = 125 nM). Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling...

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  • I-BET762

    Biovision | I-BET762 | 2628

    I-BET762 (GSK525762) is a highly potent, selective and cell-permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 (IC₅₀ of ~35 nM). It inhibits myeloma cell...

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  • I-BET726

    Biovision | I-BET726 | B1569

    I-BET276 is a potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC₅₀ = 41 nM), BRD3 (IC₅₀ = 31 nM), and BRD4 (IC₅₀ = 22 nM).I-BET276 is a potent, and...

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  • IACS-010759

    Biovision | IACS-010759 | B2231

    IACS-010759 is a potent and selective Oxidative Phosphorylation Inhibitor (IC₅₀ < 10 nM) with potential antineoplastic activity. IACS-010759 robustly inhibits proliferation and induces apoptosis in...

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  • Hyperforin. DCHA

    Biovision | Hyperforin. DCHA | 2153

    Displays a variety of biological activities including anti-bacterial, anti-inflammatory, anticancer and anti-angiogenic effects. Also acts as an antidepressant and anxiolytic agent. Regulates...

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  • HPI-1

    Biovision | HPI-1 | 2410

    HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits...

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  • HM-30181

    Biovision | HM-30181 | B1285

    HM-30181 is a third-generation P-glycoprotein (P-gp) inhibitor. In an in vitro, HM-30181 displays a high selectivity for P-gp and its potency is 20–50 times higher than that of tariquidar (Cat. No...

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  • Hh-Ag1.5

    Biovision | Hh-Ag1.5 | B2160

    Hh-Ag 1.5 is a potent and selective agonist of the Hh pathway (Smoothened/Smo agonist) (EC₅₀ = 1 nM).Hh-Ag 1.5 is a potent and selective agonist of the Hh pathway (Smoothened/Smo agonist) (EC₅₀ = 1...

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  • HG-10-012-01

    Biovision | HG-10-012-01 | 2604

    Brain-permeable. HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 and the G2019S mutant (IC₅₀ values are ~20.3 nM and ~ 3.2 nM, respectively). It significantly inhibits Ser910 and...

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  • Herbimycin A

    Biovision | Herbimycin A | 2748

    Herbimycin A is an ansamycin antibiotic isolated from Streptomyces sp. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2. Herbimycin A reverts tyrosine...

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  • Heptelidic Acid

    Biovision | Heptelidic Acid | 2215

    A sesquiterpene antibiotic, isolated from Trichoderma sp. A potent and selective glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibitor. Binds to the essential Cys149 residue in the catalytic...

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  • HC Toxin

    Biovision | HC Toxin | 2728

    HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its...

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  • HBX-41108

    Biovision | HBX-41108 | 9608

    HBX-41108 is a potent inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). HBX-41108 treatment stabilizes p53,...

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  • HA 130

    Biovision | HA 130 | B1192

    HA 130 is a potent and eversible inhibitor of autotaxin (ATX) (IC₅₀ = 28 nM). It does not affect the activity of any proteasomal protease or related enzymes. HA-130 rapidly decreases plasma...

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  • H-7 dihydrochloride

    Biovision | H-7 dihydrochloride | 9543

    H-7 is a Protein kinase inhibitor that inhibits the activity of PKA, PKC, PKG and MLCK with IC₅₀ values of 3.0, 6.0, 5.8 and 97.0 µM, respectively.H-7 is a Protein kinase inhibitor that inhibits the...

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  • H3B-6527

    Biovision | H3B-6527 | B1647

    H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.H3B-6527 is an orally bioavailable inhibitor of human...

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  • GYY 4137

    Biovision | GYY 4137 | 1908

    A slow-releasing, water-soluble hydrogen sulfide (H₂S) donor. Displays vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive)...

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  • GW-786034

    Biovision | GW-786034 | 1916

    Cell-permeable. A potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor and c-kit,...

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  • GW-7647

    Biovision | GW-7647 | 9571

    GW-7647 is a potent, selective agonist of human and murine PPARα. It activates human PPARα, PPARγ, and PPARδ with EC₅₀ values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay...

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  • GW-6471

    Biovision | GW-6471 | 9453

    GW-6471 is a potent PPARα antagonist (IC₅₀ = 240 nM). It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor. GW-6471...

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  • GW-5074

    Biovision | GW-5074 | 2412

    Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective...

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  • GW501516

    Biovision | GW501516 | 1971

    A selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and...

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  • GW-441756

    Biovision | GW-441756 | B1147

    GW-441756 is potent and specific inhibitor of Trk A (tropomyosin-related kinase A) tyrosine kinase (IC₅₀ = 2 nM). This inhibition of TrkA reduces cell proliferation and enhances the effects of...

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  • GW-4064

    Biovision | GW-4064 | B2278

    GW-4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC₅₀ = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves...

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  • GW-3965 hydrochloride

    Biovision | GW-3965 hydrochloride | 9402

    GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα...

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  • GW-0742

    Biovision | GW-0742 | B1100

    GW 0742 is a potent and selective PPARδ agonist (EC₅₀ = 1.1 nM) that displays 1,000-fold selectivity over other human PPAR subtypes. Therapeutically has shown to have effect on pulmonary damage,...

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  • GW 9508

    Biovision | GW 9508 | 2817

    GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) with pEC₅₀ of 7.32; 100-fold selective against GPR120. Inactive against a range of other GPCRs, kinases,...

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