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  • GSNO

    Biovision | GSNO | 1580

    Carrier of nitric oxide, relaxing smooth muscles and inhibiting platelet activation.GSNO is a carrier of nitric oxide, relaxing smooth muscles and inhibiting platelet activation.Biovision | 1580 |...

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  • GSK-J1 sodium salt

    Biovision | GSK-J1 sodium salt | 2260

    A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including...

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  • GSK-J1 (Free acid)

    Biovision | GSK-J1 (Free acid) | 2761

    GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ...

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  • GSK-961081

    Biovision | GSK-961081 | B1590

    GSK-961081 is a bi-functional molecule with both muscarinic antagonism and β2-agonism (MABA) properties. GSK-961081 displays high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3...

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  • GSK-650394

    Biovision | GSK-650394 | B2093

    GSK-650394 is a potent inhibitor of serum- and glucocorticoid-regulated kinase (IC₅₀s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over...

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  • GSK-583

    Biovision | GSK-583 | B1301

    GSK-583 is a highly potent and selective Inhibitor of RIP2 Kinase (IC₅₀ = 5 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation...

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  • GSK-503

    Biovision | GSK-503 | 9538

    GSK-503 is a potent EZH2 inhibitor with potential anticancer activity. Increased activity of the epigenetic modifier EZH2 has been associated with different cancers. In a melanoma mouse model,...

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  • GSK-4112

    Biovision | GSK-4112 | 9663

    GSK-4112 is a selective agonist for REV-ERBα (EC₅₀ = 0.4 μM). At 10 μM, GSK-4112 can reset the circadian rhythm in a phasic manner by inhibiting expression of the circadian target gene bmal1 and...

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  • GSK-3787

    Biovision | GSK-3787 | 2400

    GSK-3787 is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor delta (PPARδ) (plC₅₀ = 6.6). It covalently binds to Cys 249 in the PPARδ binding site.GSK-3787 is...

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  • GSK-3117391

    Biovision | GSK-3117391 | B2375

    GSK-3117391 is a potent histone deacetylase (HDAC) inhibitorGSK-3117391 is a potent histone deacetylase (HDAC) inhibitorBiovision | B2375 | GSK-3117391 DataSheetAlternate Name/Synonyms:...

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  • GSK-3039294

    Biovision | GSK-3039294 | B2374

    GSK-3039294 is a potent small molecule inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils for the depletion of serum amyloid-P (SAP) component from the circulation.GSK-3039294 is...

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  • GSK-2982772

    Biovision | GSK-2982772 | B2232

    GSK-2982772 is a potent and ATP-competitive receptor-interacting protein-1 (RIP1) kinase inhibitor (IC₅₀ = 1 nM).GSK-2982772 is a potent and ATP-competitive receptor-interacting protein-1 (RIP1)...

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  • GSK-2879552

    Biovision | GSK-2879552 | B1044

    GSK-2879552 is a potent, selective, mechanism-based inactivator of Lysine Specific Demethylase 1 (LSD1)/ CoRepressor for Element-1-Silencing Transcription factor (CoREST) activity. GSK-2879552 binds...

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  • GSK2830371

    Biovision | GSK2830371 | 2578

    GSK2830371 is an allosteric Wip1 (Wild type p53-induced phosphatase) inhibitor (IC₅₀ of 6 nM). It binds to a flap subdomain that regulates Wip1's enzymatic activity and substrate recognition. Due to...

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  • GSK-2801

    Biovision | GSK-2801 | 9553

    GSK-2801 is a potent, selective and cell-permeable inhibitor of the BAZ2 family of bromodomain containing proteins. GSK-2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257...

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  • GSK-269962

    Biovision | GSK-269962 | 9654

    GSK-269962 is a potent Rho kinase (ROCK) inhibitor (IC₅₀ values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a...

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  • GSK-2656157

    Biovision | GSK-2656157 | 9466

    GSK-2656157 is a potent, selective and ATP-competitive inhibitor of PERK (protein kinase R-like ER kinase) enzyme activity with an IC₅₀ of 0.9 nM; displays high selectivity for PERK against a panel...

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  • GSK-2606414

    Biovision | GSK-2606414 | 9467

    GSK-2606414 is a potent and selective inhibitor of protein kinase R-like ER kinase (PERK) with IC₅₀ value of 0.4 nM. Displays >1000-fold selectivity for PERK over HR1 and PKR. GSK-2606414 inhibits...

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  • GSK-2334470

    Biovision | GSK-2334470 | B1555

    GSK-2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) (IC₅₀ = 10 nM). It does not suppress activity on other 96 kinases, including Aurora,...

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  • GSK2330672

    Biovision | GSK2330672 | B1102

    GSK2330672 is a highly selective, potent, nonabsorbable ASBT(Apical Sodium dependent bile acid transporter) inhibitor (IC₅₀ = 42 nM). It lowers glucose in an animal model of type 2 diabetes...

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  • GSK-2194069

    Biovision | GSK-2194069 | B1571

    GSK-2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS (human Fatty Acid Synthase).GSK-2194069 is a potent and specific inhibitor of the β-ketoacyl reductase...

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  • GSK2190915

    Biovision | GSK2190915 | B1891

    GSK2190915 (Fiboflapon) is a potent FLAP (5-lipoxygenase-activating protein) inhibitor (IC₅₀ = 2.9 nM).GSK2190915 (Fiboflapon) is a potent FLAP (5-lipoxygenase-activating protein) inhibitor (IC₅₀ = 2...

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  • GSK-2126458

    Biovision | GSK-2126458 | 1961

    Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ),...

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  • GSK-2110183

    Biovision | GSK-2110183 | B1089

    GSK-2110183 is a potent, selective, and ATP-competitive pan-Akt inhibitor with IC₅₀s of 0.08, 2 and 2.6 nM for Akt1, Akt2, and Akt3 respectively.GSK-2110183 is a potent, selective, and...

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  • GSK-2018682

    Biovision | GSK-2018682 | B1967

    GSK-2018682 is a potent sphingosine -1 phosphate receptor (S1PR)-1 agonist; useful for the treatment of multiple sclerosis. GSK-2018682 induces acute, transient and non-symptomatic decreases in heart...

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  • GSK-1940029

    Biovision | GSK-1940029 | B2373

    GSK-1940029 is a potent stearoyl-coA desaturase (SCD) inhibitorGSK-1940029 is a potent stearoyl-coA desaturase (SCD) inhibitorBiovision | B2373 | GSK-1940029 DataSheetAlternate Name/Synonyms:...

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  • GSK1349572

    Biovision | GSK1349572 | 2288

    A potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that displays potent antiviral activity.GSK1349572 is a potent, second generation HIV integrase inhibitor (IC₅₀ = 2.7 nM) that...

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  • GSK1325756

    Biovision | GSK1325756 | B1103

    GSK1325756 is a selective and reversible CXCR2 antagonist with IC₅₀ value of 12.5 nM. GSK1325756 displays anti-inflammatory effects in various preclinical and clinical models.GSK1325756 is a...

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  • GSK-1292263

    Biovision | GSK-1292263 | B1556

    GSK-1292263 is a novel GPR119 receptor agonist and is used for the treatment of type 2 diabetes. GSK1292263 improves glucose regulation in animal models of diabetes, but has no effect on plasma...

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  • GSK1278863

    Biovision | GSK1278863 | B1107

    GSK-1278863 is a novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (HIF-PHI). Hypoxia-inducible factor−prolyl hydroxylase inhibitors stimulate endogenous EPO synthesis and induce effective...

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  • GSK-1120212

    Biovision | GSK-1120212 | 1960

    A potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9 nM) enzymes with potential antineoplastic activity.GSK-1120212 is a potent and selective allosteric...

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  • GSK-1059615

    Biovision | GSK-1059615 | 9450

    GSK-1059615 is a potent, reversible, ATP-competitive inhibitor of PI3Kα (IC₅₀ = 2 nM). It inhibits proliferation in BT474 cells and attenuates MAPK signaling.GSK-1059615 is a potent, reversible,...

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  • GSK-0660

    Biovision | GSK-0660 | 2897

    GSK-0660 is a selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ, respectively).GSK-0660 is a selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥...

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  • GS-9973

    Biovision | GS-9973 | 2669

    GS-9973 is a potent and highly selective Syk (spleen tyrosine kinase) inhibitor (IC₅₀ = 7.7 nM).GS-9973 is a potent and highly selective Syk (spleen tyrosine kinase) inhibitor (IC₅₀ = 7.7 nM)...

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  • GPNA (monohydrate)

    Biovision | GPNA (monohydrate) | B2150

    GPNA is a substrate for γ-glutamyl transpeptidase. GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine...

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  • Gossypin

    Biovision | Gossypin | 2374

    A glucoside occurring in cotton and Hubiscus flowers that acts as a potent antimelanoma agent. Gossypin inhibits human melanoma cell proliferation, in vitro, in melanoma cell lines that harbors both...

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  • GNE 477

    Biovision | GNE 477 | B1657

    GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR.GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for...

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  • GN25

    Biovision | GN25 | 9430

    GN25 blocks Snail binding to p53 and induces p53 expression in cancer cells in a KRas dependent manner. Oncogenic KRas has been shown to inhibit p53 function by inducing Snail to bind and eliminate...

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  • GLYX13

    Biovision | GLYX13 | B2287

    GLYX-13 is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Displays nootropic, neuroprotective and antinociceptive activity, and...

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  • GLX-351322

    Biovision | GLX-351322 | B2340

    GLX-351322 is a potent NADPH oxidase-4 (NOX-4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing...

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