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Biovision

  • Muristerone A

    Biovision | Muristerone A | 2184

    A potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. An analog of ecdysone with similar properties to Ponasterone A (Cat. No. 2183). Inducer of ecdysone-inducible gene...

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  • MTT Reagent

    Biovision | MTT Reagent | 2809

    MTT is a tetrazolium salt used for determining cell viability. MTT produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living...

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  • MTS Reagent

    Biovision | MTS Reagent | 2808

    MTS reagent is a tetrazolium inner salt useful for determining the number of viable cells in proliferation or chemosensitivity assays. MTS is bioreduced by cells into a colored formazan product that...

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  • MSX-130

    Biovision | MSX-130 | B2157

    MSX-130 is CXCR4 AntagonistMSX-130 is CXCR4 AntagonistBiovision | B2157 | MSX-130 DataSheetAlternate Name/Synonyms: 2,2'-(1,4-Phenylene)bis[4,5-diphenyl-1H-imidazole]Appearance: Cystalline...

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  • MSC-2530818

    Biovision | MSC-2530818 | B1975

    MSC-2530818 is a potent, selective CDK8 Inhibitor (IC₅₀ = 2.6 nM). It displays potent inhibition of phospho-STAT1SER727, an established biomarker of CDK8 activity. MSC2530818 demonstrates potent...

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  • MRL-24

    Biovision | MRL-24 | 2764

    Cell-permeable. MRL-24 displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30...

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  • MPEP hydrochloride

    Biovision | MPEP hydrochloride | B1151

    MPEP hydrochloride is a highly selective and potent non-competitive antagonist at the mGlu5 (metabotropic glutamate receptor subtype 5) receptor subtype (IC₅₀ = 36 nM). It is a positive allosteric...

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  • MOZ-IN-3

    Biovision | MOZ-IN-3 | B2245

    MOZ-IN-3 is a potent inhibitor of MOZ, a member of histone acetyltransferases (IC₅₀ = 55 nM).MOZ-IN-3 is a potent inhibitor of MOZ, a member of histone acetyltransferases (IC₅₀ = 55 nM).Biovision |...

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  • MoTP

    Biovision | MoTP | 1852

    A useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance mechanisms. Specifically ablates zebrafish larval melanocytes or melanoblasts, and this melanocytotoxicity...

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  • Monensin A Sodium

    Biovision | Monensin A Sodium | B1623

    Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. It preferentially forms complexes with monovalent cations to...

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  • MnTBAP Chloride

    Biovision | MnTBAP Chloride | 2058

    A cell-permeable superoxide dismutase (SOD) mimetic and potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Protects T...

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  • MN64

    Biovision | MN64 | B1127

    MN64 is a potent and selective tankyrase (TNKS) inhibitor (IC₅₀ values of 6 and 72 nM for TNKS1 and TNKS2 respectively). It has no effect on PARP-1 or PARP-2 (IC₅₀ > 19 µM). Through its effects on...

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  • MMP-13 inhibitor

    Biovision | MMP-13 inhibitor | 2392

    CL-82198 is a selective inhibitor of MMP-13 (IC₅₀ = 10 µM). It displays no activity against MMP-1, MMP-9 or TACE.CL-82198 is a selective inhibitor of MMP-13 (IC₅₀ = 10 µM). It displays no activity...

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  • MMAE

    Biovision | MMAE | B2344

    MMAE (Monomethyl auristatin E) is a synthetic derivative of dolastatin 10 that functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. Suppresses tumor cell viability in vitro...

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  • MLS-573151

    Biovision | MLS-573151 | 1929

    Cell-permeable. A potent and specific inhibitor of Cdc42, a small GTPase of the Rho subfamily (IC₅₀ = 2 µM).MLS-573151 is a potent and specific inhibitor of Cdc42, a small GTPase of the Rho subfamily...

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  • MLR-1023

    Biovision | MLR-1023 | 2685

    MLR-1023 is an allosteric activator of Lyn kinase (EC₅₀ = 63 nM). It reduces blood glucose levels without increasing insulin secretion in vivo. MLR-1023 does not activate peroxisome...

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  • MLN-9708

    Biovision | MLN-9708 | B2195

    MLN-9708 is a prodrug of Ixazomib citrate (MLN-2238). MLN-9708 is an orally bioavailable next-generation proteasome inhibitor (PI) with potential potent anticancer activity in both hematologic and...

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  • MLN8237

    Biovision | MLN8237 | 2718

    MLN8237 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ =1.2 nM). It displays >200-fold higher selectivity for Aurora kinase A over Aurora kinase B. Displays antineoplastic activity...

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  • MLN-8054

    Biovision | MLN-8054 | B1943

    MLN-8054 is a potent and selective inhibitor of Aurora kinase A (IC₅₀ = 4 nM). Displays 40-fold selectivity for Aurora A over Aurora B.MLN-8054 is a potent and selective inhibitor of Aurora kinase A...

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  • MLN-4924

    Biovision | MLN-4924 | 2566

    A potent and selective inhibitor of NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8)-activating enzyme (NAE) (IC₅₀ = 4.7 nM) with potential anticancer activity. NAE activates...

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  • MLN2480

    Biovision | MLN2480 | B1706

    MLN 2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in clinical trials.MLN 2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in clinical trials.Biovision | B1706 | MLN2480...

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  • ML-7 hydrochloride

    Biovision | ML-7 hydrochloride | B2000

    ML-7 hydrochloride is a selective MLCK (myosin light chain kinase) inhibitor (Ki = 0.3 μM). Displays reversible, ATP-competitive inhibition of Ca²⁺-calmodulin-dependent and -independent smooth muscle...

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  • ML-365

    Biovision | ML-365 | B2076

    ML-365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC₅₀ values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated...

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  • ML-354

    Biovision | ML-354 | 9415

    ML-354 is a selective PAR4 antagonist (IC₅₀ = 140 nM). Displays 71-fold selectivity for PAR4 over PAR1 (PAR-1 IC₅₀ = 10 μM).ML-354 is a selective PAR4 antagonist (IC₅₀ = 140 nM). Displays 71-fold...

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  • ML-35

    Biovision | ML-35 | B2077

    ML-335 is a potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels activator with EC₅₀ of 14.3 and 5.2 uM, respectively.ML-335 is a potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2)...

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  • ML-324

    Biovision | ML-324 | 2763

    Cell-permeable. ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection...

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  • ML243

    Biovision | ML243 | 2515

    ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line...

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  • Ml241

    Biovision | Ml241 | 2697

    ML241 is a potent, selective, and reversible inhibitor of the AAA ATPase p97 (IC₅₀ = 100 nM). It blocks p97-dependent proteasome substrate with an IC₅₀ of ~ 3500 nM.ML241 is a potent, selective, and...

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  • ML-240

    Biovision | ML-240 | B1142

    ML-240 is an ATP-competitive inhibitor of the D2 domain of the p97 ATPase (IC₅₀ = 110 nM). It disrupts the endoplasmic reticulum-associated degradation and autophagy pathways, preventing the...

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  • ML230

    Biovision | ML230 | B2389

    A selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor. displays selectivity toward ABCG2 over ABCB1ML230 is a selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor...

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  • ML-204

    Biovision | ML-204 | 9448

    ML-204 is a selective blocker of TRPC4 channels. Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; shows no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8...

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  • ML-162

    Biovision | ML-162 | B2304

    ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ...

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  • ML161

    Biovision | ML161 | 2689

    ML161 is an allosteric Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC₅₀ = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Also...

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  • ML130

    Biovision | ML130 | 1974

    Cell-permeable. A selective NOD1 (nucleotide-binding oligomerization domain 1) inhibitor. Selectively inhibits NOD1-dependent activation of NF-kB in HEK293 cells (IC₅₀ = 0.56±0.04 µM). Displays high...

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  • MK-8931

    Biovision | MK-8931 | B1315

    MK-8931 is a potent BACE1 inhibitor. MK-8931 binds significantly to β-secretase.MK-8931 is a potent BACE1 inhibitor. MK-8931 binds significantly to β-secretase.Biovision | B1315 | MK-8931...

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  • MK-7655

    Biovision | MK-7655 | B2289

    MK-7655 is a potent and selective β-lactamase inhibitor. It restores imipenem-susceptibility in imipenem-resistant K. pneumoniae and P. aeruginosa when used at concentrations of 12.5 and 4.7 μM,...

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  • MK-571 sodium

    Biovision | MK-571 sodium | 2692

    MK-571 sodium is the sodium salt of the multidrug resistance protein-1 (MRP1) inhibitor MK-571 (Cat. No. 2691).MK-571 sodium is a selective, CysLT1 receptor antagonist. It blocks the binding of...

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  • MK-571

    Biovision | MK-571 | 2691

    MK 571 is a selective, CysLT1 receptor antagonist. It blocks the binding of leukotriene LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively...

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  • MK-5172

    Biovision | MK-5172 | B2118

    MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease...

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  • MK-4827 (Tosylate)

    Biovision | MK-4827 (Tosylate) | B2003

    MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumor models with loss of BRCA and...

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