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Biovision

  • NSC-319726

    Biovision | NSC-319726 | 9439

    NSC-319726 is a reactivator of mutant p53. It restores WT structure and function to the p53(R175) mutant. NSC-319726 kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft...

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  • NSC-23925

    Biovision | NSC-23925 | 2686

    NSC-23925 is a potent plasma membrane glycoprotein 1(Pgp1) inhibitor. It inhibits Pgp1 and reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 directly inhibits the function...

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  • NSC-207895

    Biovision | NSC-207895 | B1228

    NSC-207895 is a cell-permeable benzofuroxan derivative that acts as a MDMX inhibitor (IC₅₀ = 2.5 µM). Activates p53 and induces apoptosis in cancer cells. Active in vitro and in vivo.NSC-207895 is a...

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  • NSC-139021

    Biovision | NSC-139021 | B2199

    NSC-139021 (ERGi-USU) is a highly selective inhibitor for the growth of ERG-positive cancer cells with IC₅₀s ranging from 30 to 400 nM. NSC-139021 displays minimal effect on normal prostate or...

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  • NS-3763

    Biovision | NS-3763 | B1814

    NS-3763 is a selective non-competitive kainate receptor antagonist. It displays selectivity for GLUK5 subunit-containing receptors (IC₅₀ values are 1.6 and > 30 mM for homomeric GLUK5 and GLUK6...

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  • NS-1643

    Biovision | NS-1643 | B1138

    NS-1643 is a hERG (Human ether-a-go-go related gene) K⁺channel activator with EC₅₀ of 10.5 μM. It shows antiarrhythmic activity in vitro and exhibits different molecular mechanisms of action at KV11...

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  • N-Oxalylglycine

    Biovision | N-Oxalylglycine | B1084

    N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell-permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC₅₀s = 250, 500, and 24 μM,...

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  • Noopept

    Biovision | Noopept | B2148

    Noopept is a novel proline-containing dipeptide with nootropic and cognition-enhancing activity. Rescues α-synuclein amyloid toxicity in cellular models. Stimulates the expression of NGF and BDNF in...

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  • NOC-18

    Biovision | NOC-18 | 2492

    A useful nitric oxide (NO) donor. NOC-18 spontaneously dissociates in a pH-dependent, first-order process with a half-life of 20 hours and 56 hours at 37°C and 22-25°C, pH 7.4, respectively, to...

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  • NLG919

    Biovision | NLG919 | 9407

    NLG919 is a potent inhibitor of indoleamine-2,3-dioxygenase (IDO)-pathway (Ki = 7 nM). Indoleamine 2,3-dioxygenase (IDO) is an enzyme with immune-suppressive properties that is commonly exploited by...

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  • NKL 22 (MDK-4154)

    Biovision | NKL 22 (MDK-4154) | B1133

    NKL 22 (also known as MDK-4154) is a cell-permeable compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. It reverses the silencing of FXN transcription in FRDA...

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  • NKH477

    Biovision | NKH477 | 9427

    NKH477 is a water-soluble analog of the adenylyl cyclase activator Forskolin (Cat. No. 1531). Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or...

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  • Nitrocefin

    Biovision | Nitrocefin | 2388

    Nitrocefin is the chromogenic cephalosporin that acts as an excellent β-lactamase substrate. It exhibits a rapid distinctive color change from yellow (max at pH 7.0 = 390 nm) to red (max at pH 7.0 =...

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  • Nimbolide

    Biovision | Nimbolide | 1891

    A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that...

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  • NIAD-4

    Biovision | NIAD-4 | 2710

    NIAD-4 is a novel class of fluorescent probe, having good blood-brain barrier permeability, specificity to amyloid-β plaques, and "turn-on" bright far-red emission upon Aβ binding. NIAD-4 has a...

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  • NG52

    Biovision | NG52 | 9420

    NG 52 (Compound 52 ) is a potent, selective, cell-permeable, and reversible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC₅₀ = 7 μM), and the related Pho85p kinase (IC₅₀ = 2 μM).NG 52...

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  • Neurodazine

    Biovision | Neurodazine | 2568

    Cell-permeable. A promoter of neurogenesis. Neurodazine induces neuronal differentiation in skeletal muscle cells. In mouse C2C12 myoblasts, neurodazine (2 μM for seven days) upregulated the...

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  • Necrosulfonamide

    Biovision | Necrosulfonamide | 9635

    Necrosulfonamide is a potent necroptosis inhibitor. It blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during...

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  • Necrostatin-7

    Biovision | Necrostatin-7 | 1866

    A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1 kinase. Nec-7 may target an additional...

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  • Necrostatin-5

    Biovision | Necrostatin-5 | 1865

    Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative...

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  • NECA

    Biovision | NECA | B2262

    NECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC₅₀ = 2.4 μM for human A2B). NECA is also reported to act as a...

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  • Nec-1s

    Biovision | Nec-1s | 2263

    A potent necroptosis inhibitor. Displays higher activity in inhibiting necroptosis in Jurkat cells than Nec-1 (Cat. No. 1864) (EC₅₀ = 210 nM versus EC₅₀ = 490 nM), as well as showing no nonspecific...

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  • NDSB-256

    Biovision | NDSB-256 | 2135

    A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates the renaturation of chemically and thermally denatured proteins. The non-detergent sulfobetaine is zwitterionic,...

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  • NDSB-221

    Biovision | NDSB-221 | 2134

    A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates the renaturation of chemically and thermally denatured proteins. The non-detergent sulfobetaine is zwitterionic,...

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  • NDSB-211

    Biovision | NDSB-211 | 2133

    A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates the renaturation of chemically and thermally denatured proteins. The non-detergent sulfobetaine is zwitterionic,...

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  • NDSB-201

    Biovision | NDSB-201 | 2132

    A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates the renaturation of chemically and thermally denatured proteins. The non-detergent sulfobetaine is zwitterionic,...

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  • NDSB-195

    Biovision | NDSB-195 | 2131

    A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates the renaturation of chemically and thermally denatured proteins. The non-detergent sulfobetaine is zwitterionic,...

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  • NDGA

    Biovision | NDGA | 2581

    NDGA is a a phenolic compound isolated from the creosote bush Larrea divaricatta that has anti-cancer activities both in vitro and in vivo. NDGA acts as a non-selective lipoxygenase (LO) inhibitor...

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  • ND-630

    Biovision | ND-630 | B2248

    ND-630 is potent, and reversible acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively. When administered chronically to Zucker...

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  • NCH 51

    Biovision | NCH 51 | B1130

    NCH-51 (PTACH) is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor (IC₅₀ of 48 nM). PTACH is predicted to exhibit a similar HDAC binding mode as that of SAHA,...

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  • NBQX disodium salt

    Biovision | NBQX disodium salt | 2759

    NBQX is a potent, selective and competitive AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor antagonist. It targets both AMPA- and kainate-sensitive glutamate receptors (IC₅₀ = 0...

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  • Nanaomycin A

    Biovision | Nanaomycin A | 2790

    Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor. It induces antiproliferative effects in three different tumor cell lines originating from different tissues. Nanaomycin A...

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  • Nafamostat Mesylate

    Biovision | Nafamostat Mesylate | 1760

    A broad-spectrum, synthetic serine protease inhibitor and an inhibitor of the classical and alternative ways of complement activation. Displays selectivity for human tryptase when used at relatively...

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  • NADP, sodium salt

    Biovision | NADP, sodium salt | 2737

    NADP⁺ is a coenzyme that is widely distributed in living matter. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).NADP, monosodium...

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  • NADP, disodium salt

    Biovision | NADP, disodium salt | 2736

    NADP⁺ is a coenzyme that is widely distributed in living matter. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).NADP⁺ is a coenzyme...

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  • NAD⁺, Free acid

    Biovision | NAD⁺, Free acid | 2734

    NAD⁺ is a major electron acceptor molecule in biological oxidations. Acts as a coenzyme for hydride-transfer enzymes and a substrate for NAD(+)-consuming enzymes, which include ADP-ribose...

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  • Myriocin (ISP-1)

    Biovision | Myriocin (ISP-1) | 2567

    A fungal metabolite with potent immunosuppressant activity that is 10-100 fold more compared to Cyclosporin A (Cat. No. 1522). It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the...

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