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Biovision

  • KT5823

    Biovision | KT5823 | 2164

    Cell-permeable. KT5823 is a derivative of K-252a (Cat. No. 2013) that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234 µM). Inhibits other kinases at much higher concentrations...

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  • KT5720

    Biovision | KT5720 | 2276

    A derivative of the protein kinase inhibitor K252a (Cat. No. 2013). Acts as a potent, selective, ATP-competitive inhibitor of protein kinase A (PKA) (Ki = 60 nM). Has no effect on PKC, PKG and MLCK...

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  • KS-176

    Biovision | KS-176 | B1272

    KS-176 is a potent and specific inhibitor of Breast Cancer Resistance Protein (BCRP) / ATP-binding cassette sub-family G member 2 (ABCG2). Displays no inhibitory activity against P-gp or MRP1.KS-176...

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  • KN-92 phosphate

    Biovision | KN-92 phosphate | B1644

    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).KN-92 is an...

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  • KM-11060

    Biovision | KM-11060 | B1076

    KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5...

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  • Kirromycin

    Biovision | Kirromycin | B1236

    Kirromycin belongs to elfermycin group of antibiotics that inhibits as a protein biosynthesis inhibitor. It is shown to interfere with the peptide transfer reaction by acting on elongation factor Tu...

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  • Ki 8751

    Biovision | Ki 8751 | 2677

    Ki 8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC₅₀ = 0.9 nM). It is >40-fold selective for VEGFR2 than c-Kit, PDGFRα and FGFR-2, little activity to EGFR, HGFR and InsR.Ki 8751...

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  • Ki 16425

    Biovision | Ki 16425 | 9545

    Ki 16425 is a LPA (Lysophosphatidic acid) receptor antagonist with selectivity for LPA1 and LPA3. It exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors,...

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  • KHS-101

    Biovision | KHS-101 | B2415

    KHS-101 is a selective inducer of neuronal differentiation. It induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Also...

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  • K858

    Biovision | K858 | B1073

    K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle...

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  • K252a

    Biovision | K252a | 2013

    An analog of Staurosporine (Cat. No. 1048) that acts as a non-selective protein kinase inhibitor. Iinhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). Potently inhibits CaMK (Ki = 1.8...

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  • JW55

    Biovision | JW55 | 2612

    JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin...

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  • JNJ-27018966

    Biovision | JNJ-27018966 | B1109

    JNJ-27018966 is an orally active μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, with powerful antidiarrheal and analgesic activity. It is believed to act locally in the enteric...

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  • JNJ-26854165

    Biovision | JNJ-26854165 | 2479

    A novel p53-activating tryptamine derivative that acts as a HDM2 (Human Double Minute-2) antagonist with potential antineoplastic activity. JNJ-26854165 inhibits the binding of the HDM2–p53 complex...

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  • JNJ-26481585

    Biovision | JNJ-26481585 | 9612

    JNJ-26481585 is a second-generation pyrimidyl-hydroxamic acid histone deacetylase (HDAC) inhibitor with high cellular potency towards Class I and II HDACs. It displays potent antineoplastic...

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  • JNJ-1661010

    Biovision | JNJ-1661010 | 2413

    Cell-permeable. A potent , selective and reversible FAAH (Fatty Acid Amide Hydrolase) inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC₅₀ = 12 nM. Displays100-fold...

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  • JNJ-10198409

    Biovision | JNJ-10198409 | B1078

    JNJ-10198409 is a potent, cell-permeable, ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell...

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  • JM6

    Biovision | JM6 | 1913

    Cell-permeable. A slow-release prodrug version of Ro 61-8048 (Cat. No. 1912-5, 25), an inhibitor of KMO (kynurenine 3-monoxygenase), the enzyme that controls the kynurenine pathway, long believed to...

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  • Jatrorrhizine

    Biovision | Jatrorrhizine | 2530

    Jatrorrhizine is a a novel tetrahydroisoquinoline alkaloid originally extracted from the Chinese herb coptidis rhizome. Protects neuronal-like cells against H₂O₂-induced toxicity. JAT also displays...

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  • IWP-3

    Biovision | IWP-3 | 2349

    An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt...

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  • Ivachtin

    Biovision | Ivachtin | 2788

    Ivachtin is a potent, reversible and non-competitive inhibitor of caspase-3 (IC₅₀ = 23 nM) that displays 10-100 fold selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T...

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  • ITF2357

    Biovision | ITF2357 | 9431

    ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1...

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  • Itaconic acid

    Biovision | Itaconic acid | 2576

    An inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Inhibits the growth of bacteria expressing isocitrate lyase. A phosphofructokinase (PFKII)...

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  • ISX9

    Biovision | ISX9 | 2563

    ISX9 promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory. Induces robust neuronal differentiation in adult...

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  • Isoxanthohumol

    Biovision | Isoxanthohumol | 2529

    Isoxanthohumol is a naturally occurring polyphenol isolated from hops that displays antioxidant, anti-inflammatory, and anti-angiogenic properties. It modulates angiogenesis and inflammation via...

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  • IRAK-1/4 Inhibitor

    Biovision | IRAK-1/4 Inhibitor | 9578

    IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC₅₀ values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC₅₀ values >10 µM in a...

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  • IQ-1S

    Biovision | IQ-1S | B1279

    IQ-1S is a potent and selective JNK3 inhibitor (IC₅₀ values are 390, 360 and 87 nM for JNK1, 2 and 3 respectively).IQ-1S is a potent and selective JNK3 inhibitor (IC₅₀ values are 390, 360 and 87 nM...

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  • IPI-549

    Biovision | IPI-549 | B1971

    IPI-549 is a potent and selective PI3Kγ Inhibitor (IC₅₀ of 16 nM). It displays no significant inhibition for a panel of 468 mutant and non-mutant protein and lipid kinases (including Class II PI3K...

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  • IPI-145

    Biovision | IPI-145 | 2445

    PI-145 is a potent inhibitor of phosphoinositide-3-kinase (PI3K)-d and PI3K-γ isoforms with potential immunomodulating and antineoplastic activities. IPI-145 prevents the activation of the...

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  • IPAM

    Biovision | IPAM | 1817

    A cell-permeable indole derivative that acts as an antioxidant and mitochondrial metabolism modifier. IPAM binds to the rate-limiting component of oxidative phosphorylation in complex I of the...

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  • INO-1001

    Biovision | INO-1001 | B2186

    INO-1001 is a potent and selective inhibitor of Poly(ADP-ribose) polymerase (PARP). Shown to inhibit endogenous poly-ADP-ribosyltransferases often present in membrane preparations with minimal effect...

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  • INK-128

    Biovision | INK-128 | 9527

    INK-128 is a potent, selective and ATP-competituve mTORC1/2 inhibitor with potential anticancer properties. Displays >200-fold less selectivity towards class I PI3-K isoforms. Recently, it has been...

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  • INCB39110

    Biovision | INCB39110 | B1894

    INCB39110 is a potent JAK1 (Janus Kinase 1) inhibitor that displays anticancer properties.INCB39110 is a potent JAK1 (Janus Kinase 1) inhibitor that displays anticancer properties.Biovision | B1894 |...

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  • INCB-024360

    Biovision | INCB-024360 | 9477

    INCB-024360 is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor ( IC₅₀ = 10 nM); displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase...

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