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Biovision

  • LY-2835219

    Biovision | LY-2835219 | B1039

    LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC₅₀ of 2 nM and 10 nM, respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates...

    £576 - £1,788
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  • LY-2795050

    Biovision | LY-2795050 | B2351

    LY-2795050 is a potent and selective κ-opioid Receptor (KOR) antagonist (IC₅₀ = 0.72 nM). Has the potential as a PET tracer to image KOR in vivo.LY-2795050 is a potent and selective κ-opioid Receptor...

    £606 - £1,918
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  • LY-2784544

    Biovision | LY-2784544 | B1914

    LY2784544 is a potent, selective and ATP-competitive JAK2 inhibitor (IC₅₀ = 3 nM). effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. LY2784544 effectively inhibits...

    £576 - £1,788
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  • LY-2603618

    Biovision | LY-2603618 | B2191

    LY-2603618 is a potent, selective and ATP-dependent inhibitor of checkpoint kinase 1 (Chk1) (IC₅₀ = 7 nM). It inhibits Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation...

    £542 - £1,656
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  • LY-2584702

    Biovision | LY-2584702 | 9445

    LY-2584702 is a potent, ATP-competitive inhibitor of p70S6K signaling, with potential antineoplastic activity. LY-2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation...

    £478 - £1,394
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  • LY-2510924

    Biovision | LY-2510924 | B2360

    LY-2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY-2510924 binds to the chemokine receptor...

    £478 - £1,394
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  • LY2228820

    Biovision | LY2228820 | B1702

    LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, but does not alter p38 MAPK activation.LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of...

    £576 - £1,788
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  • LY-2157299

    Biovision | LY-2157299 | 9475

    LY-2157299 is a potent and selective TGFβ receptor I (TβRI) inhibitor (IC₅₀ = 56 nM). LY-2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. It also shows dose dependent...

    £508 - £1,428
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  • LY-2109761

    Biovision | LY-2109761 | 9605

    LY-2109761 is a highly potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with Ki of 38 nM and 300 nM respectively. It has been used to study the role of TGF-β signaling in...

    £708 - £2,296
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  • LY-2090314

    Biovision | LY-2090314 | B1043

    LY-2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 1.5 NM for GSK-3α and 0.9 nM for GSK-3β). LY-2090314 plays an important role in many...

    £542 - £1,656
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  • LY 294002

    Biovision | LY 294002 | 1667

    A specific and cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 1.40 µM).LY 294002 is a specific and cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI...

    £444 - £1,180
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  • LXS-196

    Biovision | LXS-196 | B2092

    LXS-196 is an orally available protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Upon oral administration, LXS-196 binds to and inhibits PKC, which...

    £674 - £2,116
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  • LX-4211

    Biovision | LX-4211 | 9623

    LX-4211 is a potent dual sodium-glucose cotransporter (SGLT)1 and SGLT2 inhibitor and an anti-diabetic agent. Sotagliflozin significantly improves glycemic control, without increasing the rate of...

    £708 - £2,296
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  • LX-2343

    Biovision | LX-2343 | B2120

    LX-2343 is a neuroprotective agent for the treatment of Alzheimer's disease. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance...

    £640 - £2,048
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  • Lumiracoxib

    Biovision | Lumiracoxib | B1987

    Lumiracoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and selective cyclooxygenase-2 (COX-2) inhibitor. Displays anti-inflammatory properties.Lumiracoxib is a...

    £478 - £1,394
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  • LuAF21934

    Biovision | LuAF21934 | B1302

    Lu AF21934 is a brain-penetrating positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4), that reduces the harmaline-induced hyperactivity.Lu AF21934 is a brain-penetrating...

    £542 - £1,558
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  • LSN-2814617

    Biovision | LSN-2814617 | B2345

    LSN-2814617 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). It acts as a potent and selective potentiator of human and rat mGlu₅ receptors in vitro,...

    £444 - £1,262
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  • Loxoribine

    Biovision | Loxoribine | 2003

    A guanosine derivative that acts as a selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.Loxoribine...

    £428 - £1,036
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  • LOXO-101

    Biovision | LOXO-101 | B2291

    LOXO-101 is a potent, ATP-competitive TRK inhibitor with IC₅₀s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100-fold selectivity over other...

    £606 - £1,918
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  • LLL12

    Biovision | LLL12 | 1792

    A Stat3 phosphorylation inhibitor. LLL12 inhibits STAT3 phosphorylation (Tyr705) and STAT3 activities and down-regulates STAT3 downstream targets; inhibits proliferation, colony formation, and cell...

    £624 - £1,656
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  • LJI-308

    Biovision | LJI-308 | B1233

    LJI308 is a potent pan-RSK inhibitor, with IC₅₀ values of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.LJI308 is a potent pan-RSK inhibitor, with IC₅₀ values of 6 nM, 4 nM, and 13 nM...

    £478 - £1,394
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  • Linamarin

    Biovision | Linamarin | 2749

    Linamarin is a cyanogenic glycoside defense compound produced by plants and insects. Found in cassava. Displays neurotoxic effects in rats. Linamarin induces memory and cognition deficits in rodents...

    £1,066 - £1,788
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  • LIMKi 3

    Biovision | LIMKi 3 | B1095

    LIMKi 3 is a potent, and cell-permeable inhibitor of LIMK1 (IC₅₀ = 7 nM) and LIMK2 (IC₅₀ = 8 nM) and inhibits coflin phosphorylation in MDA-MB-231 breast cancer cells without affecting tubulin...

    £576 - £1,788
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  • LH-846

    Biovision | LH-846 | 9423

    LH-846 is a potent and selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε andα); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent...

    £640 - £2,048
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  • Leucettine L41

    Biovision | Leucettine L41 | 2617

    A potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems...

    £508 - £1,362
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  • L-DON

    Biovision | L-DON | B1955

    L-DON is a glutamine antagonist produced naturally by Streptomyces; it inhibits several glutamine-dependent enzyme pathways as well as acts as an inhibitor of the mitochondrial enzyme, glutaminase...

    £444 - £1,262
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  • LDK-378

    Biovision | LDK-378 | B1928

    LDK-378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 200 pM). It displays weaker inhibition against IGF-1R, InsR, and STK22D (IC50s = 8, 7, and 23 nM, respectively), and...

    £444 - £1,262
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  • LDE-225

    Biovision | LDE-225 | 2892

    LDE225 is a potent and selective antagonist of Smoothened (Smo) with IC₅₀ values of 2.5 nM and 1.3 nM for human and mouse Hedgehog, respectively. LDE-225 induces dose-related inhibition of Hh and...

    £576 - £1,788
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  • LB-100

    Biovision | LB-100 | B2031

    LB-100 is a potent protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. LB-100 is a potent protein phosphatase 2A (PP2A) inhibitor with IC₅₀s of 0.85...

    £576 - £1,870
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  • LAQ824

    Biovision | LAQ824 | 2634

    LAQ824 (Dacinostat) is a potent HDAC inhibitor (IC₅₀ = 32 nM) that displays significant activity against multiple myeloma.LAQ824 (Dacinostat) is a potent HDAC inhibitor (IC₅₀ = 32 nM) that displays...

    £444 - £1,262
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  • L-838,417

    Biovision | L-838,417 | B1281

    L-838, 417 is a subtype-selective GABAA receptor partial agonist. It selectively binds to α1, α2, α3 and α5 subunits (Kivalues are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy...

    £576 - £1,788
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  • L-755,507

    Biovision | L-755,507 | B1116

    L-755,507 is a partial agonist of β3-adrenergic receptors (EC₅₀ = 0.43 nM). It displays >440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC₅₀s = 580 and >10,000 nM, respectively)...

    £640 - £2,048
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  • L-67

    Biovision | L-67 | 9633

    L-67 is a competitive human DNA ligase inhibitor, that inhibits DNA ligases I and III with IC₅₀ values of 10 μM and 10 μM. L-67 significantly increases the cytotoxicity of DNA damaging agents. L-67...

    £576 - £1,788
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  • L-189

    Biovision | L-189 | 9674

    L-189 is a DNA ligase I, III and IV inhibitor (IC₅₀ values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki= 5 μM for DNA ligase I). L-189 inhibits base excision repair (BER) and...

    £478 - £1,394
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