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Biovision

  • Canagliflogin

    Biovision | Canagliflogin | B1597

    Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), that belongs to a new class of anti-hyperglycaemic agents used in type 2 diabetes mellitus (T2DM).Canagliflozin is...

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  • Camostat mesylate

    Biovision | Camostat mesylate | B2145

    Camostat mesylate is a synthetic, orally bioavailable is a serine protease inhibitor. Used for the treatment of chronic pancreatitis. It attenuates pancreatic fibrosis via inhibition of monocytes and...

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  • Calphostin C

    Biovision | Calphostin C | 2611

    A potent and highly specific cell-permeable protein kinase C (PKC) inhibitor . The inhibition of PKC is light-dependent. Also inhibits PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light...

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  • Calcein AM

    Biovision | Calcein AM | 1755

    A cell-permeable, non-fluorescent acetoxymethyl ester derivative of Calcein that gets hydrolyzed inside the cell by esterases. The loss of the acetoxymethyl group also enables calcein to readily bind...

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  • CAL-101 (GS-1101)

    Biovision | CAL-101 (GS-1101) | 2613

    CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for...

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  • C7280948

    Biovision | C7280948 | B1153

    C7280948 is an inhibitor of PRMT1 (Protein arginine N-methyltransferase 1) with IC₅₀ value of 12.75 μM. It serves as a useful tool in studying the role of PRMT1 in epigenetics. PMRT1 has been...

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  • C2-Dihydroceramide

    Biovision | C2-Dihydroceramide | 2391

    A useful negative control for C2 Ceramide (Cat. No. 2390-5, 25). Also acts as an autophagy inducer.C2-dihydroceramide is a useful negative control for C2 Ceramide (Cat. No. 2390-5, 25). Also acts as...

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  • C2 Ceramide

    Biovision | C2 Ceramide | 2390

    A cell-permeable ceramide analog. Induces apoptosis in a variety of cell types. Stimulates ceramide-activated protein phosphatases and activates ceramide-activated protein kinases.C2 ceramide is a...

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  • C K-666

    Biovision | C K-666 | B2147

    CK-666 is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC₅₀ = 4 µM for human ARP2/3. Blocks actin nucleation and radically alters...

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  • BX-517

    Biovision | BX-517 | B1764

    BX-517, also known as PDK1 inhibitor2, is a potent and selective PDK1 inhibitor that binds to the ATP binding pocket.BX-517, also known as PDK1 inhibitor2, is a potent and selective PDK1 inhibitor...

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  • BX-471

    Biovision | BX-471 | B2407

    BX-471 is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM; displays 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.BX-471 is a potent and selective non-peptide CCR1...

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  • BS3 Crosslinker

    Biovision | BS3 Crosslinker | 2327

    KEY FEATURES: • Amine-reactive; has a non-cleavable spacer with arm length of 11.4 Å • Water-soluble • Membrane-impermeable APPLICATIONS: • Crosslinking of proteins through reaction with...

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  • Bryostatin 1

    Biovision | Bryostatin 1 | 2513

    Bryostatin 1 is a naturally occurring macrocyclic lactone that binds to and activates protein kinase C, but its biological effects differ greatly from those induced by other protein kinase C...

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  • Brigatinib analog

    Biovision | Brigatinib analog | B2025

    Brigantinib alalog is an analog of Brigatinib (AP26113) (Cat.No. 9675), a phosphine oxide-containing ALK inhibitor. It potently inhibits ALK (IC₅₀ = 0.07 nM) over IGF-1R and InsR (IC₅₀s = 3.2 and 100...

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  • BRD-7552

    Biovision | BRD-7552 | B2258

    BRD-7552 is an inducer of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD-7552 dose-dependently increases PDX1 and insulin gene...

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  • BRD-73954

    Biovision | BRD-73954 | 9596

    BRD-73954 ia a potent and selective HDAC inhibitor with IC₅₀ of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.BRD-73954 ia a potent and selective HDAC inhibitor with IC₅₀ of 36 nM and 120 nM for...

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  • BQ-788 Sodium Salt

    Biovision | BQ-788 Sodium Salt | B1554

    BQ-788 is a potent and selective antagonist of endothelin (ET) B-receptor (IC₅₀ = 1.2 nM). BQ-788 is a good tool for demonstrating the role of ET-1 and ET(B) receptor subtypes in physiological and/or...

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  • BQ-610

    Biovision | BQ-610 | B1553

    BQ-610 is a highly potent and selective ETAR (ETA receptor) antagonist (IC₅₀ = 20 nM) that ttenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of...

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  • BQ-123 Sodium Salt

    Biovision | BQ-123 Sodium Salt | B1552

    BQ-123 sodium is a potent and selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). It also inhibits ET-1 receptor binding and blocks...

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  • Bosutinib (SKI-606)

    Biovision | Bosutinib (SKI-606) | 1584

    Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent. It is used to treat...

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  • Bostrycin

    Biovision | Bostrycin | B2128

    Bostrycin is a tetrahydroanthraquinone isolated from Bostrychonema aloestre. It induces mitochondria-mediated apoptosis in the yeast saccharomyces cerevisiae, inhibits proliferation of human lung...

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  • Borrelidin

    Biovision | Borrelidin | 2367

    A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed...

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  • Bohemine

    Biovision | Bohemine | B1040

    Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor IC₅₀ = 1 µM). Arrests cell cycle in the G/S boundary and activates mature bovine oocytes. Bohemine is...

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  • BODIPY-Cyclopamine

    Biovision | BODIPY-Cyclopamine | 2160

    A fluorescent Cyclopamine (Cat. No. 1578-5) derivative that retains potency in Shh signaling inhibition (IC₅₀ = 150 nM).BODIPY-Cyclopamine is a fluorescent Cyclopamine (Cat. No. 1578-5) derivative...

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  • BN-82002

    Biovision | BN-82002 | B2371

    BN-82002 is a cell-permeable CDC25 Phosphatase Inhibitor. BN-82002 is a potent, cell-permeable, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6...

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  • BMS-986205

    Biovision | BMS-986205 | B1839

    BMS-986205 is a potent and selective IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Does not have much effect on IDO2 (indoleamine 2,3-dioxygenase 2) or TDO (Tryptophan 2,3-dioxygenase).BMS-986205...

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  • BMS-777607

    Biovision | BMS-777607 | 2455

    A potent, selective and ATP-competitive Met kinase superfamily inhibitor (IC₅₀ = 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM for c-Met, Axl, RON, and Tyro-3, respectively). it was >40-fold selective for Met...

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  • BMS-708163

    Biovision | BMS-708163 | B1622

    BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectivelyBMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with...

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  • BMS-663068

    Biovision | BMS-663068 | B2299

    BMS-663068 (Fostemsavir) is a potent HIV-1 attachment inhibitor. Fostemsavir is a prodrug of the small-molecule inhibitor BMS-626529 (Cat. No. B1557) which inhibits human immunodeficiency virus type...

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  • BMS-626529

    Biovision | BMS-626529 | B1557

    BMS-626529 is a potent attachment inhibitor of HIV-1 gp120 with IC₅₀ values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, respectively.BMS-626529 is a potent attachment...

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  • BMS-582949

    Biovision | BMS-582949 | B1704

    BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor.BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor.Biovision...

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  • BMS-299897

    Biovision | BMS-299897 | 9606

    BMS-299897 is a potent, brain-permeant γ-secretase inhibitor (IC₅₀ = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain,...

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  • BMN-673

    Biovision | BMN-673 | B1861

    BMN-673 is a potent and selective PARP1/2 inhibitor with Ki values of 1.2 and 0.9 nM, respectively. It had no effect on panels of 72 receptors, ion channels, and enzymes. BMN-673 displays selective...

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  • BML210

    Biovision | BML210 | B1128

    BML-210 (also known as CAY10433), is a histone deacetylase (HDAC) inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer...

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  • BLU-554

    Biovision | BLU-554 | B2359

    BLU-554 is a potent inhibitor of recombinant fibroblast growth factor receptor 4 (FGFR4) IC₅₀ < 10 nM). It also inhibits phosphorylation of ERK (IC₅₀ < 10 nM), a marker of FGFR4 inhibition, in...

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  • Bleomycin sulfate

    Biovision | Bleomycin sulfate | 2246

    An antitumor antibiotic isolated from Streptomyces verticillus. Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism...

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