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Biovision

  • AS 602801

    Biovision | AS 602801 | B1687

    AS 602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.AS 602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and...

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  • ARN-509

    Biovision | ARN-509 | 9535

    ARN-509 is a selective and competitive androgen receptor (AR) inhibitor (IC₅₀ = 16 nM). ARN-509 selectively binds the androgen receptor and impairs its nuclear translocation and DNA binding to...

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  • AR-42 (HDAC-42)

    Biovision | AR-42 (HDAC-42) | 2716

    AR-42 is a potent histone deacetylase inhibitor (HDACi). It induces growth inhibition, cell- cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 also promotes hyperacetylation of H3, H4,...

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  • APY-0201

    Biovision | APY-0201 | 9564

    APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC₅₀ = 5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. Also acts as a...

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  • Apramycin Sulfate

    Biovision | Apramycin Sulfate | B1521

    Apramycin is an aminoglycoside antibiotic that binds the deep groove of RNA and effectively inhibits ribosomal translocation blocking protein synthesis. Displays bactericidal activity against most...

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  • Apilimod mesylate

    Biovision | Apilimod mesylate | B1129

    Apilimod is a small molecule that inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases through the prevention of nuclear translocation of c-Rel. It suppresses the...

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  • APD-597

    Biovision | APD-597 | 9637

    APD-597 is a GPR119 agonist with EC₅₀ of 46 nM for hGPR119. Could be a potential anti-diabetic agent for treatment of type 2 diabetes.APD-597 is a GPR119 agonist with EC₅₀ of 46 nM for hGPR119. Could...

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  • Apatinib mesylate

    Biovision | Apatinib mesylate | B1608

    Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitorApatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitorBiovision |...

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  • Antimycin A

    Biovision | Antimycin A | 2247

    Antimycin A, isolated from Streptomyces sp., is a mixture of Antimycins A1, A2, A3 and A4. Inhibits mitochondrial electron transport, specifically between cytochromes b and c1. Induces apoptosis,...

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  • AN-2728

    Biovision | AN-2728 | B2220

    AN-2728 is a boron-based, topical anti-inflammatory agent that acts as a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 0.11 µM). It is less potent against PDE1A, PDE3A, and PDE7A (IC₅₀s = 6.12, 6.41,...

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  • Ampicillin sodium

    Biovision | Ampicillin sodium | 2484

    Ampicillin sodium is a β-lactam antibiotic structurally related to penicillin. Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell...

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  • AMMC iodide

    Biovision | AMMC iodide | 2873

    AMMC iodide is a useful substrate for the human cytochrome P450 CYP2D6 isozyme. It is demethylated to the fluorescent product 3-[2-(N,N-diethyl-N-methyl ammonium)ethyl]-7-hydroxy-4-methylcoumarin...

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  • Amlodipine besylate

    Biovision | Amlodipine besylate | 2378

    A L-type calcium channel blocker and an anti-hypertensive agent. Amlodipine displays vasoprotective effects in cardiovascular disease and inhibits Ca²⁺-induced contractions in depolarized rat aorta...

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  • Aminopurvalanol A

    Biovision | Aminopurvalanol A | 2205

    A cell-permeable, reversible and competitive inhibitor of cyclin-dependent kinases. IC₅₀ values are: CDK1/cyclin B (33 nM), CDK2/cyclin A (33 nM), CDK2/cyclin E (28 nM) and CDK5/p35 (20 nM)...

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  • Amikacin

    Biovision | Amikacin | B1514

    Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and...

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  • AMI-5

    Biovision | AMI-5 | 2300

    AMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases...

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  • AMG-Tie2

    Biovision | AMG-Tie2 | B1612

    AMG-Tie2 is a highly potent, non-selective inhibitor of Tie-2AMG-Tie2 is a highly potent, non-selective inhibitor of Tie-2Biovision | B1612 | AMG-Tie2 DataSheetAlternate Name/Synonyms: AMGTie2; AMG...

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  • AMG-925

    Biovision | AMG-925 | B1959

    AMG-925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC₅₀ of 1 nM and 3 nM, respectively. It inhibits the proliferation of a panel of human tumor cell lines including Colo205...

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  • AMG-900

    Biovision | AMG-900 | B1343

    AMG-900 is a highly sensitive and orally bioavailable inhibitor of Aurora Kinase with IC50 values of 5 nmol/LAMG-900 is a highly sensitive and orally bioavailable inhibitor of Aurora Kinase with IC50...

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  • AMG-232

    Biovision | AMG-232 | 9556

    AMG232 is a highly potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC₅₀ = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft...

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  • AM-095

    Biovision | AM-095 | 9581

    AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibitsLPA-driven chemotaxis of CHO...

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  • Alsterpaullone

    Biovision | Alsterpaullone | 1897

    Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ =35 nM). Also inhibits CDK2/cyclin A, CDK2/cyclin E (IC₅₀ = 200 nM), CDK5/p25 (IC₅₀ = 40 nM), CDK5/p35 (IC₅₀ = 40 nM) and GSK-3β...

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  • Alendronate sodium

    Biovision | Alendronate sodium | 2168

    Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. It inhibits bone resorption in vitro with an IC₅₀ value of 2 nM. Also acts as a...

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  • Aldosterone

    Biovision | Aldosterone | B2153

    Aldosterone is a steroid hormone produced by the outer portion (cortex) of the adrenal gland and its secretion is regulated by the renin-angiotensin system. It plays an important role in...

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  • Akt-I-1

    Biovision | Akt-I-1 | B1610

    Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3Biovision | B1610 |...

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  • AKR1C3 Inhibitor III

    Biovision | AKR1C3 Inhibitor III | 2424

    A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 88 nM). Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4. Does not display any...

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  • AKR1C3 Inhibitor II

    Biovision | AKR1C3 Inhibitor II | 2404

    A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM)...

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  • AKR1C3 Inhibitor I

    Biovision | AKR1C3 Inhibitor I | 2403

    A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3. In repeat assays it showed an IC₅₀ of 0.013 ± 0.003 μM for AKR1C3, compared with 20.3 ± 3.8 μM against...

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  • AKP-11

    Biovision | AKP-11 | B1973

    AKP-11 is a novel S1P1 (Sphingosine-1-phosphate receptor 1) agonist with potential therapeutic potential for treatment of MS and related autoimmune disorders.AKP-11 is a novel S1P1...

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  • AHU-377

    Biovision | AHU-377 | 9520

    AHU-377 is a prodrug that is activated in vivo by esterases to form an active compound LBQ657 which acts as a potent and selective neprilysin inhibitor. Neprilysin is a protease responsible for the...

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  • Agistatin E

    Biovision | Agistatin E | B1023

    Agistatin E is a tricyclic analog of Agistatin A. Acts as a cholesterol biosynthesis inhibitor. Mycotoxin.Agistatin E is a tricyclic analog of Agistatin A. Acts as a cholesterol biosynthesis...

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  • Agistatin D

    Biovision | Agistatin D | B1022

    Agistatin D is a cholesterol biosynthesis inhibitor. Isolated from fungus A 6239.Agistatin D is a cholesterol biosynthesis inhibitor. Isolated from fungus A 6239.Biovision | B1022 | Agistatin D...

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  • Agistatin B

    Biovision | Agistatin B | B1021

    Agistatin B is a cholesterol biosynthesis inhibitor. Isolated from fungus FH-A 6239.Agistatin B is a cholesterol biosynthesis inhibitor. Isolated from fungus FH-A 6239.Biovision | B1021 | Agistatin B...

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