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Biovision

  • AG-881

    Biovision | AG-881 | B1953

    AG-881 is a potent and selective inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP⁺],...

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  • AG 1478

    Biovision | AG 1478 | 1800

    Cell-permeable. A potent EGFR Tyrosine Kinase (TK) inhibitor with an IC₅₀ of 3 nM. Only weakly inhibits PDGFR and HER2-NEU kinases (IC₅₀ >100 µM).AG 1478 is a potent EGFR Tyrosine Kinase (TK)...

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  • Aftin-5

    Biovision | Aftin-5 | 2575

    Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells...

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  • AF353

    Biovision | AF353 | B2318

    A potent P2X3/P2X2/3 receptor antagonist; inhibits human and rat P2X3 (pIC₅₀ = 8.0).AF-353 is a potent P2X3/P2X2/3 receptor antagonist; inhibits human and rat P2X3 (pIC₅₀ = 8.0).Biovision | B2318 |...

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  • AEE-788

    Biovision | AEE-788 | 9658

    AEE-788 is a potent EGFR and VEGFR inhibitor (IC₅₀ values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src...

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  • AEBSF.HCl

    Biovision | AEBSF.HCl | 1644

    A specific, irreversible serine protease inhibitor. Inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin and trypsin. A stable, non-toxic and better soluble alternative to PMSF.AEBSF...

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  • ADW-742

    Biovision | ADW-742 | B2197

    ADW-742 is an ATP-competitive inhibitor of IGF1R (IC₅₀ in the range of 0.1-0.2 μM) with potential anticancer activity. It synergistically enhances the sensitivity of SCLC (small cell lung cancer) to...

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  • ACY-1215

    Biovision | ACY-1215 | 2629

    ACY-1215 is a potent, cell-permeable and selective inhibitor of histone deacetylase 6 (HDAC6) (IC₅₀ = 5 nM). ACY-1215 is 12-, 10-, 11 and 21-fold less active against HDAC1, HDAC2, HDAC3 and HDAC8,...

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  • Ac-WEHD-pNA

    Biovision | Ac-WEHD-pNA | B2282

    Ac-WEHD-pNA is a useful colorimetric substrate for group I caspases (caspase-1, -4, and -5). Cleavage of the substrate by a caspase releases pNA, which can be detected by its absorbance at 405 nm...

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  • Ac-WEHD-AFC

    Biovision | Ac-WEHD-AFC | B2214

    Ac-WEHD-AFC is a useful fluorogenic substrate for group I caspases (caspase-1, -4, and -5). Caspase activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at...

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  • Ac-VEID-pNA

    Biovision | Ac-VEID-pNA | B2283

    Ac-VEID-pNA, is a colorimetric substrate for caspase-6 and related cysteine proteases. Cleavage of the substrate by a caspase results in the release of pNA, which can be detected by its absorbance at...

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  • ACT-129968

    Biovision | ACT-129968 | B2316

    A potent and selective CRTh2 antagonist. CRTh2 is a G-protein-coupled receptor for prostaglandin D2 (PGD2), a key mediator in inflammatory disorders.ACT-129968 is a potent and selective CRTh2...

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  • Aconitine

    Biovision | Aconitine | 2423

    Aconitine is diterpene alkaloid derived from the tubers of aconitinum plants. It is a neurotoxin that opens TTX(tetrodotoxin)-sensitive Na⁺ channels in the heart and other tissues, and is used for...

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  • Acivicin

    Biovision | Acivicin | B1028

    Acivicin is an antibiotic that inhibits γ-glutamyl transpeptidase (γ-GT), an enzyme involved in transferring g-glutamyl groups in the cell membranes of kidneys, heart, brain, and pancreas. Acivicin...

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  • ACC2 Inhibitor

    Biovision | ACC2 Inhibitor | 1717

    Cell-permeable. A potent and selective inhibitor of ACC2 (Acetyl-CoA Carboxylase) (IC₅₀ = 28 nM for hACC2 vs 210 nM for hACC1 in in vitro studies).ACC2 inhibitor is a potent and selective inhibitor...

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  • ABT-888

    Biovision | ABT-888 | 1620

    Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and...

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  • ABT-869

    Biovision | ABT-869 | 1615

    ABT-869 is multi-targeted inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR, IC₅₀ value of 4 nM), but has much less activity (IC₅₀ values >1 µM) against unrelated receptor...

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  • ABT751

    Biovision | ABT751 | 2836

    ABT751 is a potent inhibitor of microtubule polymerization. It binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell...

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  • ABT-494

    Biovision | ABT-494 | B1947

    ABT-494 is a potent and selective Janus kinase JAK-1 inhibitor (IC₅₀ = 43 nM). ABT-494 is 74-fold more selective for JAK-1 over JAK-2 and 58-fold more selective for JAK-1 over JAK-3.ABT-494 is a...

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  • ABL-001

    Biovision | ABL-001 | B1949

    ABL-001 is a potent allosteric inhibitor of BCR-ABL. ABL001 binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation. ABL001 prevents emergence of resistant...

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  • ABC294640

    Biovision | ABC294640 | B1231

    ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2, preventing...

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  • ABC-1183

    Biovision | ABC-1183 | B2221

    ABC-1183 is a potent and selective dual GSK3α/β and CDK9 inhibitor.ABC-1183 is a potent and selective dual GSK3α/β and CDK9 inhibitor.Biovision | B2221 | ABC-1183 DataSheetAlternate Name/Synonyms:...

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  • Abametapir

    Biovision | Abametapir | 9665

    Abametapir is a metalloprotease inhibitor potentially useful for the treatment of head lice infestation. It is the active ingredient of Xeglyze Lotion.Abametapir is a metalloprotease inhibitor...

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  • AAL-993

    Biovision | AAL-993 | 2740

    AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC₅₀ = 130 nM), VEGFR-2 (IC₅₀ = 23 nM) and VEGFR-3 (IC₅₀ = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit...

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  • A77 1726

    Biovision | A77 1726 | 1973

    Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks...

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  • A37

    Biovision | A37 | B1577

    A37 is a aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor (IC₅₀ = 4.6 μM; Ki = 300 nM). Displays selectivity for ALDH1A1 over eight other ALDH isoforms. A37 disrupts OC spheroid formation and cell...

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  • 8-Br-cGMP

    Biovision | 8-Br-cGMP | 1838

    A cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium...

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  • 8-Br-cAMP

    Biovision | 8-Br-cAMP | 1837

    A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and...

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  • 7-Nitroindazole

    Biovision | 7-Nitroindazole | 2360

    A non-selective, reversible and competitive inhibitor of NOS isoforms in vitro. The IC₅₀ values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively...

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  • 7BIO

    Biovision | 7BIO | 9690

    7BIO is a caspase- independent nonapoptotic cell death inducer. Also acts as an ATP-competitive FLT3 inhibitor and DYRK1A and DYRK 2 (Dual-specificity tyrosine phosphorylation-regulated kinase)...

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  • 6-Gingerol

    Biovision | 6-Gingerol | 2507

    Bioactive compound found in ginger (Zingiber officinale). Displays antioxidant, anti-inflammatory and antitumor properties. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages...

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  • 6-Azauridine

    Biovision | 6-Azauridine | B1024

    6-Azauridine is a synthetic triazine analog of uridine with antimetabolite activity. 6-Azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono,...

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  • 680C91

    Biovision | 680C91 | 2292

    Cell-permeable. A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO, Ki = 51 nM.) Tryptophan is metabolized to the endogenous AHR ligand by TDO which may be inhibited by 680C91...

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  • 4SC-202

    Biovision | 4SC-202 | B1230

    4SC-202 is an orally available potent HDAC inhibitor (HDACi) specific for class I HDAC isoenzymes with IC50s of 1.2/1.12/0.57 µM for HDAC1/2/3; displays high selectivity over ClassIIa/IIb/III HDACs...

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