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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • Elbasvir

    Biovision | Elbasvir | B3087

    Elbasvir is a potent inhibitor of Hepatitis C virus (HCV), non-structural protein 5A (NS5A). It is active against many HCV genotypes with EC₅₀ values in the picomolar range (0.0003 nM-3.4 nM). It is used in combination with other antiviral drugs to treat...

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  • Darunavir

    Biovision | Darunavir | B3086

    Darunavir is an HIV-1 protease inhibitor with an IC₅₀ of 3 nM and cytoxicity of 74.4 μM. It is also also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells...

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  • Amastatin hydrochloride

    Biovision | Amastatin hydrochloride | B3085

    Amastatin is an inhibitor of aminopeptidase A and leucine aminopeptidase (IC₅₀ values of 0.54 μg/ml and 0.5 μg/ml). It does not show any significant inhibition of aminopeptidase B, trypsin, chymotrypsin, elastase, papain, pepsin or thermolysin. It is a...

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  • Trabectedin

    Biovision | Trabectedin | B3084

    Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding proteins, DNA repair pathways and shows potent antitumor...

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  • Dexmedetomidine

    Biovision | Dexmedetomidine | B3083

    Dexmedetomidine is an imidazole derivate and an active d-isomer of medetomidine. Medetomidine is a racemate of the stereoisomers levomedetomidine and dexmedetomidine. Dexmedetomidine is a potent α2-adrenergic receptor agonist which shows analgesic,...

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  • BIBR-1532

    Biovision | BIBR-1532 | B3082

    BIBR-1532 is a highly potent mixed-type non-competitive inhibitor of telomerase. It inhibits telomerase in a dose-dependent manner, with an IC₅₀ of 93 nM. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. It induces...

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  • (-)-Equol

    Biovision | (-)-Equol | B3081

    S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα) with Ki values of 0.73 and 6.4 nM respectively. It...

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  • Sodium dichloroacetate

    Biovision | Sodium dichloroacetate | B3080

    Sodium dichloroacetate is an inhibitor of pyruvate dehydrogenase kinase (PDK). It shows IC₅₀ values of 183 μM and 80 μM for PDK2 and PDK4 respectively. DCA causes apoptosis in cancer cells and inhibits tumor growth.Sodium dichloroacetate is an inhibitor...

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  • GRL-0617

    Biovision | GRL-0617 | B3079

    GRL-0617 is a potent inhibitor of the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro cleaves the viral polyproteins. GRL-0617 inhibits SARS-CoV and SARS-CoV-2 PLpro in vitro with IC₅₀...

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  • Mapracorat

    Biovision | Mapracorat | B3078

    Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis and Eczema. It inhibits TNFα secretion from activated...

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  • Sarecycline

    Biovision | Sarecycline | B3077

    Sarecycline is a semi-synthetic tetracycline, narrow-spectrum antibiotic, being developed to treat patients suffering from moderate to severe acne vulgaris. Sarecycline is more active than tetracycline against tet(K) and tet(M) gram-positive bacterial...

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  • GS-441524

    Biovision | GS-441524 | B3076

    GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA. It shows broad spectrum activity in cell based assays...

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  • ONC-201

    Biovision | ONC-201 | B3075

    ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25 μM-5 μM and crosses the blood-brain barrier. It inactivates...

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  • EZSolution™ LDN193189

    Biovision | EZSolution™ LDN193189 | B3074

    EZSolution™ LDN193189 is a 10.9 mM (5 mg in 1.13 ml) solution of LDN193189 (Cat. No. B3067) in anhydrous DMSO.EZSolution™ LDN193189 is a 10.9 mM (5 mg in 1.13 ml) solution of LDN193189 (Cat. No. B3067) in anhydrous DMSO.Biovision | B3074 | EZSolution™...

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  • LIN28 inhibitor LI71

    Biovision | LIN28 inhibitor LI71 | B3073

    LIN28 is an RNA-binding protein that regulates the maturation of the let-7 microRNAs through its two distinct cold shock and zinc-knuckle domains. LIN28 inhibitor LI71 binds the cold shock domain of LIN28 and suppresses the activity of LIN28 against...

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  • Afatinib dimaleate

    Biovision | Afatinib dimaleate | B3072

    Afatinib is an irreversible dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase. It shows IC₅₀ values of 0.5 nM and 14 nM for EGFR kinase and HER2 kinase respectively. It inhibits...

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  • (S)-Crizotinib

    Biovision | (S)-Crizotinib | B3071

    (S)-crizotinib is a low nanomolar inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase (MTH1 or NUDT1) whereas the (R)-enantiomer shows IC₅₀ values in the micromolar range. MTH1 aids in RAS-transformed cells to overcome oncogene-induced senescence by...

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  • Golgicide A

    Biovision | Golgicide A | B3070

    ADP-ribosylation factor 1 (Arf1) plays an important role in regulating secretory traffic and membrane transport within the Golgi. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs). Golgicide A is a potent, specific and reversible...

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  • CHIR-124

    Biovision | CHIR-124 | B3069

    CHIR-124 is a quinolone-based inhibitor of Checkpoint kinase-1 (Chk1). It potently and selectively inhibits Chk1 in vitro with an IC₅₀ of 0.3 nM. It interacts synergistically with topoisomerase poisons (e.g., camptothecin) in inhibiting the growth of...

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  • Riluzole

    Biovision | Riluzole | B3068

    Riluzole is a benzothiazole derivative which inhibits glutamatergic neurotransmission and blocks voltage-dependent sodium channels (ED₅₀ = 2.3 μM). It reduces the uptake of GABA from neuronal synapse. Riluzole suppresses glutamate-induced seizures in...

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  • LDN-193189

    Biovision | LDN-193189 | B3067

    LDN-193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC₅₀≥ 500 nM)...

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  • Quisinostat hydrochloride

    Biovision | Quisinostat hydrochloride | B3066

    Quisinostat is an inhibitor of histone deacetylase (HDAC). It shows activity toward HDAC enzymes with highest potency for recombinant HDAC1 (IC₅₀ = 0.11 nM) in vitro. The IC₅₀ values for HDAC 2 and 3 are 0.33 nM and 4.8 nM respectively. It shows broad...

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  • GSA 10

    Biovision | GSA 10 | B3065

    GSA 10 is a novel, potent activator of the smoothened receptor (Smo). GSA 10 acts at Smo and promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 µM). GSA 10 does not recognize the classic...

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  • JTE-607

    Biovision | JTE-607 | B3064

    JTE-607 is a multiple cytokine inhibitor. It inhibits cytokine production specifically in human peripheral blood mononuclear cells without causing immunosuppression. It inhibits tumor necrosis factor-α (TNF-α), interleukins IL-1β, IL-6, IL-8 and IL-10...

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  • R-7050

    Biovision | R-7050 | B3063

    R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR associated death domain protein (TRADD) and receptor...

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  • C87

    Biovision | C87 | B3062

    C87 is an inhibitor of Tumor Necrosis Factor α (TNFα). It binds to human TNFα with a KD of 110 nM and potently inhibits TNFα-induced cytotoxicity in L929 cells with an IC₅₀ of 8.73 μM. It effectively blocks TNFα-triggered signaling pathways and...

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  • BAY-678

    Biovision | BAY-678 | B3061

    BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15 nM and 600 nM for human and rat neutrophil elastase respectively and IC₅₀...

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  • BAY-677

    Biovision | BAY-677 | B3060

    BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE with IC₅₀>2000 nM.BAY-677 is a negative control for...

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  • Tucidinostat

    Biovision | Tucidinostat | B3059

    Tucidinostat is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 95 nM, 160 nM, 67 nM and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10 respectively. It shows potent antitumor activity. It inhibits several human derived tumor cell lines, such...

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  • Gabexate mesylate

    Biovision | Gabexate mesylate | B3058

    Gabexate is an inhibitor of serine proteases. It inhibits plasma kallikrein, thrombin, plasmin, factor Xa with Ki values of 0.2 μM, 0.97 μM, 1.6 μM and 8.5 μM. It exerts an anticoagulant effect on the clotting activity of thrombin. It inhibits...

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  • E-64d

    Biovision | E-64d | B3057

    E-64d is a synthetic analog of E-64 which is a membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases. It inhibits cathepsins B and L in intact lysosomes and cells. It (20-200 µg/ml) induces cell cycle arrest at the G2/M phase in A431...

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  • Miglustat hydrochloride

    Biovision | Miglustat hydrochloride | B3056

    Miglustat is an inhibitor of the N-linked oligosaccharide processing enzymes α-glucosidase I and II. It inhibits rat testicular enzymes ceramide-glucosyltransferase and β-glucosidase 2 with IC50 values of 32 and 81 μM respectively. Miglustat is used for...

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  • Prazosin

    Biovision | Prazosin | B3055

    Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs). The affinity estimates (pKi) for inhibition of [3H]-prazosin binding to CHO-K1 cells expressing cloned human α1A, α1B and α1D adrenoceptors are 9.0, 9.9 and 9.5 respectively. It also inhibits...

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  • FITC-Tyramide

    Biovision | FITC-Tyramide | B3054

    Tyramide signal amplification is an enzyme-catalyzed deposition of tyramide on or near a protein or nucleic acid in situ. The enzyme horseradish peroxidase (HRP) converts the labelled tyramide substrate into a highly reactive form that can covalently...

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  • Siramesine

    Biovision | Siramesine | B3053

    Siramesine is an agonist for sigma-2 (σ2) receptor. It is selective for σ2 over σ1 with IC₅₀ values of 0.12 nM and 17 nM respectively. It shows potent anxiolytic-like effects in rodents. The minimal effective dose (MED) is 0.18 nmol/kg (0.1 microg/kg)...

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  • Omeprazole

    Biovision | Omeprazole | B3052

    Omeprazole is a proton pump inhibitor (PPI). It inhibits gastric H+/K+ ATPase with an IC₅₀ of 1.1 μM. It shows competitive inhibition of cytochrome P450 enzyme CYP2C19 activity with a Ki of 2-6 μM. It is used for the treatment of gastroesophageal reflux...

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  • RIPA-56

    Biovision | RIPA-56 | B3051

    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces...

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  • Astemizole

    Biovision | Astemizole | B3050

    Astemizole is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG potassium channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole shows synergistic antiproliferative effects with calcitriol in breast cancer...

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  • PRE-084 Hydrochloride

    Biovision | PRE-084 Hydrochloride | B3049

    PRE-084 is a high affinity sigma receptor 1 (σ1) agonist. It shows Ki values of 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively and an IC₅₀ of 44 nM in the sigma receptor assay. It does not show significant activity for PCP and other receptors...

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  • S1RA (E-52862)

    Biovision | S1RA (E-52862) | B3048

    S1RA is a highly selective sigma-1 (σ1) receptor antagonist. It shows high affinity for σ1 receptors with Ki values of 17 nM and 23.5 nM for human and guinea pig σ1 receptors respectively but no significant affinity for the σ2 receptors with Ki values of...

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  • NE-100 hydrochloride

    Biovision | NE-100 hydrochloride | B3047

    NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals...

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  • SA4503 dihydrochloride

    Biovision | SA4503 dihydrochloride | B3046

    SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ receptor in guinea pig brain membranes. It shows Ki values of...

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  • Pridopidine

    Biovision | Pridopidine | B3045

    Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is 100-fold higher than the affinity for D2 Receptor...

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  • Ditolylguanidine

    Biovision | Ditolylguanidine | B3044

    Ditolylguanidine is a sigma receptor (σR) agonist with neuroprotective activity. It shows Kd values of 21.9 nM and 57.4 nM for σ2 and σ1 receptor respectively. Combined treatment with Ditolylguanidine (5 mg/kg) and memantine induces antidepressant-like...

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  • GBR-12909

    Biovision | GBR-12909 | B3043

    GBR-12909 is a potent and selective inhibitor of dopamine uptake (Ki = 1 nM). It inhibits dopamine uptake in tissue slices obtained from rat neostriatum at nanomolar concentrations. GBR-12909 (10 mg/kg IP) produces a dose-dependent decrease in the...

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  • Cepharanthine

    Biovision | Cepharanthine | B3042

    Cepharanthine is an alkaloid extracted from the plant Stephania cepharantha Hayata. It shows antimalarial, antiviral, anti-inflammatory, and antitumor activities. The IC₅₀ values against different strains of Plasmodium falciparum range beween 0.927 μM...

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  • Nitazoxanide

    Biovision | Nitazoxanide | B3041

    Nitazoxanide is a nitrothiazole benzamide with anti-parasitic and anti-viral activity. It inhibits pyruvate-ferredoxin oxidoreductase in protozoa and anaerobic bacteria. It inhibits many anerobes in vitro, with MIC₉₀ values of 0.06 μg/ml-4 μg/ml. It...

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  • Umifenovir

    Biovision | Umifenovir | B3040

    Umifenovir is an indole derivative with broad-spectrum antiviral activity. It inhibits virus-mediated fusion with target membrane and blocks virus entry into target cells. It shows antiviral activity against many enveloped or non-enveloped RNA or DNA...

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  • N4-Hydroxycytidine

    Biovision | N4-Hydroxycytidine | B3039

    N4-Hydroxycytidine is a ribonucleoside analog with broad-spectrum antiviral activity. The prodrug of N4-hydroxycytidine is EIDD-2801. N4-Hydroxycytidine is active against influenza, Ebola, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)and...

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  • Triclabendazole

    Biovision | Triclabendazole | B3038

    Triclabendazole is a benzimidazole anthelminthic drug that binds to tubulin. TCBZ is used to treat liver fluke (Fasciola hepatica) infections in cattle and humans. It is effective against fascioliasis in sheep at a dose of 10 mg/body weight...

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  • Siponimod (BAF-312)

    Biovision | Siponimod (BAF-312) | B3037

    Siponimod is an orally bioavailable agonist of the sphingosine-1-phosphate (S1P) receptor that is selective for S1P1 and S1P5 with EC₅₀ values of 0.39 and 0.98 nM respectively, in a GTPγS-binding assay. Siponimod (0.3 or 3 mg/kg/day mg/kg/day) reduces...

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  • Meglumine

    Biovision | Meglumine | B3036

    Meglumine is a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. It is used as an excipient for drug formulations and for preparing salts. The meglumine or combined meglumine-sodium salts of triiodinated...

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