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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • Cystamine dihydrochloride

    Biovision | Cystamine dihydrochloride | B2982

    Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s disease. It has an anti-inflammatory effect and reduces...

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  • NQTrp

    Biovision | NQTrp | B2981

    NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12 neuronal cell line. It also increases the life span and...

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  • AC-186

    Biovision | AC-186 | B2980

    AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated with increased risk of Alzheimer’s disease. AC-186...

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  • TGN-020

    Biovision | TGN-020 | B2979

    TGN-020 is an inhibitor of aquaporin 4 (AQP4), the most abundant water channel in brain. It inhibits AQP4 inhibitor with an IC₅₀ of 3 μM in vitro. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduces ischemic cerebral edema associated with...

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  • AMTB hydrochloride

    Biovision | AMTB hydrochloride | B2978

    AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the frequency of volume-induced urinary bladder...

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  • TCS 5861528

    Biovision | TCS 5861528 | B2977

    TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values of 14.3 and 18.7 μM, respectively. Chronic...

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  • ASP7663

    Biovision | ASP7663 | B2976

    ASP7663 is a selective transient receptor potential ankyrin 1 (TRPA1) activator. It activates human, rat and mouse TRPA1 receptors with EC₅₀ values of 510 nM, 540 nM and 500 nM, respectively. It releases 5-HT from QGP-1 cells. It enhances colonic...

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  • R-59-022

    Biovision | R-59-022 | B2975

    R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and potentiates aggregation of thrombin-stimulated platelets...

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  • JNJ-17203212

    Biovision | JNJ-17203212 | B2974

    JNJ-17203212 is a reversible and potent antagonist of transient receptor potential vanilloid 1 (TRPV1) with pKi values of 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively. It Inhibits capsaicin- and low pH- induced channel activation with...

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  • A-839977

    Biovision | A-839977 | B2973

    A-839977 is a potent antagonist of the purinergic receptor P2X subtype 7 (P2X7). A-839977 potently blocks BzATP-induced calcium influx at recombinant human, rat and mouse P2X7 receptors with IC₅₀ values of 20 nM, 42 nM and 150 nM respectively. It also...

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  • JNJ-47965567

    Biovision | JNJ-47965567 | B2972

    JNJ-47965567 is a potent and selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux. JNJ-47965567 attenuates Bz-ATP induced calcium flux in 1321N1...

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  • CA-074

    Biovision | CA-074 | B2971

    CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC₅₀ of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It inhibits cathepsins H, L and calpain with IC₅₀ values of...

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  • 666-15

    Biovision | 666-15 | B2970

    666-15 is a potent and selective inhibitor of cyclic adenosine monophosphate response element binding protein (CREB)-mediated gene transcription with an IC₅₀ of 81 nM. The IC₅₀ values for inhibiting the growth of A549, MCF-7, MDA-MB-231, MDA-MB-468 cell...

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  • COG133

    Biovision | COG133 | B2969

    COG 133 is a fragment of Apolipoprotein E (APOE) that mimics the anti-inflammatory and neuroprotective effects of the intact apoE protein. It functions through the low-density lipoprotein receptor-related protein (LRP). It reduces the symptoms of...

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  • Probucol

    Biovision | Probucol | B2968

    Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. The use of probucol is limited, because it leads to the...

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  • Gramicidin A

    Biovision | Gramicidin A | B2967

    Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from Bacillus brevis. Gramicidin A is a linear channel-forming ionophore pentadecapeptide that forms a hydrophilic membrane pore that permits the rapid passage...

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  • Anidulafungin

    Biovision | Anidulafungin | B2966

    Anidulafungin is an echinocandin antifungal drug. It inhibits (1→3)-β-D-glucan synthase which is required for synthesis of the fungal cell wall. It shows potent in vitro activity against Aspergillus and Candida species (MIC₅₀ of 0.03 to 4 μg/ml),...

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  • PLX5622 (free base)

    Biovision | PLX5622 (free base) | B2965

    PLX5622 is an inhibitor of colony-stimulating factor 1 receptor (CSF1R) tyrosine kinase with a Ki of 5.9 nM. It causes sustained and specific elimination of microglia. As a result of microglial depletion, plaques fail to form in the parenchymal space in...

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  • Astragalin

    Biovision | Astragalin | B2964

    Astragalin is a flavonoid isolated from leaves of persimmon, green tea seeds, wine and American pokeweed. It shows anti-inflammatory and anti-oxidant activity. It dose-dependently (20-80 µg/ml) inhibits IL-1β-stimulated nitric oxide and prostaglandin E2...

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  • Benserazide hydrochloride

    Biovision | Benserazide hydrochloride | B2963

    Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. It causes an increase in the...

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  • CAY10505

    Biovision | CAY10505 | B2962

    CAY10505 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), selectively inhibiting the γ isoform with an IC₅₀ of 30 nM. It inhibits the α, β, and δ isoforms of PI3K with IC₅₀ values of 0.94, 20, and 20 μM, respectively. It significantly inhibits...

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  • Boceprevir

    Biovision | Boceprevir | B2961

    Boceprevir is a protease inhibitor that binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication, with a Ki of 14 nM. It inhibits the NS3/4A protease in...

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  • Allicin

    Biovision | Allicin | B2960

    Allicin is a natural product isolated from garlic (Allium sativum) that exhibits many biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities. Allicin (5-10 µM) dose-dependently inhibits cell adhesion, invasion,...

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  • Thiamet G

    Biovision | Thiamet G | B2959

    Thiamet G is a potent and selective inhibitor of O-GlcNAcase with a Ki value of 21 nM. It increases cellular O-GlcNAc-modified protein levels with an EC₅₀ of 30 nM and blocks phosphorylation of tau protein both in cultured PC-12 cells and in rats (200...

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  • Importazole

    Biovision | Importazole | B2958

    Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in...

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  • Daltroban

    Biovision | Daltroban | B2957

    Daltroban is an antagonist of thromboxane A2 receptor. Daltroban (20 mg/kg per h i.v.) protects the myocardium from ischaemic injury by preventing ischaemia-induced leukocytosis in cats. Infusion (1 mg/kg) of daltroban as a bolus results in a...

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  • Aphidicolin

    Biovision | Aphidicolin | B2956

    Aphidicolin is a natural tetracyclic diterpene antibiotic which shows antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases...

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  • Flubendazole

    Biovision | Flubendazole | B2955

    Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per...

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  • Valbenazine

    Biovision | Valbenazine | B2954

    Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2). VMAT2 plays an important role in the packaging of monoamines into presynaptic vesicles. Valbenazine shows Ki values of 110 and 150 nM in rat striatum homogenates and human...

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  • Wogonoside

    Biovision | Wogonoside | B2953

    Wogonoside is a flavonoid with antioxidant, anti-cancer and anti-angiogenic activity. Wogonoside inhibits the growth of U937 and HL-60 cells cells. It arrests the cell cycle at the G0/G1 phase and decreases the G2/M and S phases in these cells in a dose...

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  • GSK 1016790A

    Biovision | GSK 1016790A | B2952

    GSK1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist that elicits calcium influx in HEK cells expressing mouse or human transient TRPV4 with EC₅₀ values of 18 and 2.1 nM, respectively. It regulates urinary bladder activity and...

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  • Tryptanthrin

    Biovision | Tryptanthrin | B2951

    Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It suppresses angiogenesis by targeting the...

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  • ONC212

    Biovision | ONC212 | B2950

    ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines at 20 μM and potently prevents colony formation at 5...

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  • Valnemulin hydrochloride

    Biovision | Valnemulin hydrochloride | B2949

    Valnemulin is a pleuromutilin antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit of bacteria. It is used to treat swine diseases including Brachyspira hyodysenteriae and Mycoplasma hyopneumoniae which cause dysentery and...

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  • Destruxin B

    Biovision | Destruxin B | B2948

    Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. It shows insecticidal and anti-cancer properties. It induces a concentration-dependent antiproliferative effect on lung adenocarcinoma A549 cells, with an IC₅₀...

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  • Destruxin A

    Biovision | Destruxin A | B2947

    Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. Destruxins show insecticidal, anti-viral, and phytotoxic properties. Destruxin A suppresses the Drosophila humoral immune response in Drosophila melanogaster. It...

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  • Sanguinarine

    Biovision | Sanguinarine | B2946

    Sanguinarine is a benzylisoquinoline alkaloid that inhibits PP2C and shows selectivity for PP2C over PP1, PP2A, and PP2B in vitro. It inhibits MKP-1 with an IC₅₀ of 10 μM and shows selectivity for MKP-1 over MKP-3. It is a potent suppressor of NF-κB...

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  • Demethoxycurcumin

    Biovision | Demethoxycurcumin | B2945

    Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of...

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  • Bisdemethoxycurcumin

    Biovision | Bisdemethoxycurcumin | B2944

    Bisdemethoxycurcumin is a curcumin analogue with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells and inhibits proliferation of different...

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  • GNE-9605

    Biovision | GNE-9605 | B2943

    GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC₅₀ of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice...

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  • GNE-0877

    Biovision | GNE-0877 | B2942

    GNE-0877 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with a Ki of 0.7 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-0877 inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice...

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  • CZC-25146

    Biovision | CZC-25146 | B2941

    CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant induced neuronal injury with EC₅₀ values of ~100 nM and...

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  • LRRK2-IN-1

    Biovision | LRRK2-IN-1 | B2940

    LRRK2-IN-1 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2). Mutations in LRRK2 are associated with Parkinson's disease. LRRK2-IN-1 inhibits wild-type and G2019S mutant LRRK2 with IC₅₀ values of 13 nM and 6 nM, respectively. It suppresses...

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  • IQA

    Biovision | IQA | B2939

    IQA is an indoloquinazoline derivative that acts as a selective and reversible casein kinase (CK2) inhibitor with an IC₅₀ of 390 nM with 100 µM ATP. It inhibits CK2 in an ATP- and GTP-competitive manner (Ki is 0.17 and 0.21 µM, respectively). It induces...

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  • VEGFR-2 inhibitor

    Biovision | VEGFR-2 inhibitor | B2938

    VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at 100 mg/kg. It shows an ED₅₀ of 16.3 mg/kg in the rat...

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  • ZXX2-77

    Biovision | ZXX2-77 | B2937

    ZXX2-77 is a benzenesulfonanilide derivative that inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. It shows more potent analgesic activity than aspirin at 30 mg/kg by po. It can be used as a lead compound to develop better COX-1 inhibitors as...

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  • WAY-265497

    Biovision | WAY-265497 | B2936

    WAY-265497 is a potent ATP-binding site-targeting inhibitor of Cdk4/D1 kinase activity with an IC₅₀ of 30 nM. It inhibits HCT116 and MCF-7 cancer cells with IC₅₀ values of 0.73 and 0.88 µM, respectively. It inhibits Cdk2/E and Cdk1/B at higher...

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  • CK2 inhibitor

    Biovision | CK2 inhibitor | B2935

    CK2 inhibitor selectively inhibits casein kinase 2 (CK2) with an IC₅₀ of 0.125 μM. CK2 is a potential protein kinase target for the development of antitumor, antiviral and anti-inflammatory drugs.CK2 inhibitor selectively inhibits casein kinase 2 (CK2)...

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  • HDAC, EGFR & HER2 inhibitor

    Biovision | HDAC, EGFR & HER2 inhibitor | B2933

    HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC₅₀ values of 6.5 nM, 3.1 nM and 19 nM respectively. It inhibits...

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  • VEGFR-2 & tubulin inhibitor

    Biovision | VEGFR-2 & tubulin inhibitor | B2932

    VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0.11 μM respectively. It shows an EC₅₀ of 9 nM for causing...

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  • BRD6929

    Biovision | BRD6929 | B2931

    BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM respectively. It shows 50–400 fold selectivity over HDAC3 with an...

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