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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • NQTrp

    Biovision | NQTrp | B2981

    NQTrp is an inhibitor of amyloid β (Aβ) oligomerization and fibrillization, with an IC₅₀ of 50 nM for formation of fibrils from Aβ1-42. It reduces the cytotoxic effect of Aβ oligomers in rat PC12...

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  • AC-186

    Biovision | AC-186 | B2980

    AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated...

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  • TGN-020

    Biovision | TGN-020 | B2979

    TGN-020 is an inhibitor of aquaporin 4 (AQP4), the most abundant water channel in brain. It inhibits AQP4 inhibitor with an IC₅₀ of 3 μM in vitro. Pretreatment with the AQP4 inhibitor TGN-020...

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  • AMTB hydrochloride

    Biovision | AMTB hydrochloride | B2978

    AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8). It inhibits icilin-induced calcium influx with a pIC₅₀ of 6.23. Intravenous administration of AMTB (3 mg/kg) decreases the...

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  • TCS 5861528

    Biovision | TCS 5861528 | B2977

    TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values...

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  • ASP7663

    Biovision | ASP7663 | B2976

    ASP7663 is a selective transient receptor potential ankyrin 1 (TRPA1) activator. It activates human, rat and mouse TRPA1 receptors with EC₅₀ values of 510 nM, 540 nM and 500 nM, respectively. It...

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  • R-59-022

    Biovision | R-59-022 | B2975

    R-59-022 is an inhibitor of Diacylglycerol (DAG) kinase with an IC₅₀ of 2.8 µM. The inhibition of Diacylglycerol kinase results in increased DAG-dependent protein kinase C (PKC) activity and...

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  • JNJ-17203212

    Biovision | JNJ-17203212 | B2974

    JNJ-17203212 is a reversible and potent antagonist of transient receptor potential vanilloid 1 (TRPV1) with pKi values of 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively. It Inhibits...

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  • A-839977

    Biovision | A-839977 | B2973

    A-839977 is a potent antagonist of the purinergic receptor P2X subtype 7 (P2X7). A-839977 potently blocks BzATP-induced calcium influx at recombinant human, rat and mouse P2X7 receptors with IC₅₀...

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  • JNJ-47965567

    Biovision | JNJ-47965567 | B2972

    JNJ-47965567 is a potent and selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP induces calcium flux. JNJ-47965567...

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  • CA-074

    Biovision | CA-074 | B2971

    CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC₅₀ of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It...

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  • 666-15

    Biovision | 666-15 | B2970

    666-15 is a potent and selective inhibitor of cyclic adenosine monophosphate response element binding protein (CREB)-mediated gene transcription with an IC₅₀ of 81 nM. The IC₅₀ values for inhibiting...

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  • COG133

    Biovision | COG133 | B2969

    COG 133 is a fragment of Apolipoprotein E (APOE) that mimics the anti-inflammatory and neuroprotective effects of the intact apoE protein. It functions through the low-density lipoprotein...

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  • Probucol

    Biovision | Probucol | B2968

    Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. The use...

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  • Gramicidin A

    Biovision | Gramicidin A | B2967

    Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from Bacillus brevis. Gramicidin A is a linear channel-forming ionophore pentadecapeptide that forms a...

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  • Anidulafungin

    Biovision | Anidulafungin | B2966

    Anidulafungin is an echinocandin antifungal drug. It inhibits (1→3)-β-D-glucan synthase which is required for synthesis of the fungal cell wall. It shows potent in vitro activity against Aspergillus...

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  • Astragalin

    Biovision | Astragalin | B2964

    Astragalin is a flavonoid isolated from leaves of persimmon, green tea seeds, wine and American pokeweed. It shows anti-inflammatory and anti-oxidant activity. It dose-dependently (20-80 µg/ml)...

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  • CAY10505

    Biovision | CAY10505 | B2962

    CAY10505 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), selectively inhibiting the γ isoform with an IC₅₀ of 30 nM. It inhibits the α, β, and δ isoforms of PI3K with IC₅₀ values of 0.94,...

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  • Boceprevir

    Biovision | Boceprevir | B2961

    Boceprevir is a protease inhibitor that binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication,...

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  • Allicin

    Biovision | Allicin | B2960

    Allicin is a natural product isolated from garlic (Allium sativum) that exhibits many biological effects including antioxidative, anticancer, antimicrobial, and antifungal activities. Allicin (5-10...

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  • Thiamet G

    Biovision | Thiamet G | B2959

    Thiamet G is a potent and selective inhibitor of O-GlcNAcase with a Ki value of 21 nM. It increases cellular O-GlcNAc-modified protein levels with an EC₅₀ of 30 nM and blocks phosphorylation of tau...

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  • Importazole

    Biovision | Importazole | B2958

    Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged...

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  • Daltroban

    Biovision | Daltroban | B2957

    Daltroban is an antagonist of thromboxane A2 receptor. Daltroban (20 mg/kg per h i.v.) protects the myocardium from ischaemic injury by preventing ischaemia-induced leukocytosis in cats. Infusion (1...

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  • Aphidicolin

    Biovision | Aphidicolin | B2956

    Aphidicolin is a natural tetracyclic diterpene antibiotic which shows antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication,...

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  • Flubendazole

    Biovision | Flubendazole | B2955

    Flubendazole is a benzimidazole carbamate anthelmintic agent. It eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection...

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  • Valbenazine

    Biovision | Valbenazine | B2954

    Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2). VMAT2 plays an important role in the packaging of monoamines into presynaptic vesicles. Valbenazine shows Ki values of 110...

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  • Wogonoside

    Biovision | Wogonoside | B2953

    Wogonoside is a flavonoid with antioxidant, anti-cancer and anti-angiogenic activity. Wogonoside inhibits the growth of U937 and HL-60 cells cells. It arrests the cell cycle at the G0/G1 phase and...

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  • GSK 1016790A

    Biovision | GSK 1016790A | B2952

    GSK1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist that elicits calcium influx in HEK cells expressing mouse or human transient TRPV4 with EC₅₀ values of 18 and 2.1 nM,...

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  • Tryptanthrin

    Biovision | Tryptanthrin | B2951

    Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It...

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  • ONC212

    Biovision | ONC212 | B2950

    ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines...

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  • Destruxin B

    Biovision | Destruxin B | B2948

    Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. It shows insecticidal and anti-cancer properties. It induces a concentration-dependent antiproliferative...

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  • Destruxin A

    Biovision | Destruxin A | B2947

    Destruxin A is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. Destruxins show insecticidal, anti-viral, and phytotoxic properties. Destruxin A suppresses the Drosophila...

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  • Sanguinarine

    Biovision | Sanguinarine | B2946

    Sanguinarine is a benzylisoquinoline alkaloid that inhibits PP2C and shows selectivity for PP2C over PP1, PP2A, and PP2B in vitro. It inhibits MKP-1 with an IC₅₀ of 10 μM and shows selectivity for...

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  • Demethoxycurcumin

    Biovision | Demethoxycurcumin | B2945

    Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in...

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  • GNE-9605

    Biovision | GNE-9605 | B2943

    GNE-9605 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC₅₀ of 19 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-9065 inhibits LRRK2...

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  • GNE-0877

    Biovision | GNE-0877 | B2942

    GNE-0877 is a selective, brain-penetrable Leucine-rich repeat kinase 2 (LRRK2) inhibitor with a Ki of 0.7 nM. Mutations in LRRK2 are associated with Parkinson's disease. GNE-0877 inhibits LRRK2...

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  • CZC-25146

    Biovision | CZC-25146 | B2941

    CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant...

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  • LRRK2-IN-1

    Biovision | LRRK2-IN-1 | B2940

    LRRK2-IN-1 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2). Mutations in LRRK2 are associated with Parkinson's disease. LRRK2-IN-1 inhibits wild-type and G2019S mutant LRRK2 with IC₅₀...

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  • IQA

    Biovision | IQA | B2939

    IQA is an indoloquinazoline derivative that acts as a selective and reversible casein kinase (CK2) inhibitor with an IC₅₀ of 390 nM with 100 µM ATP. It inhibits CK2 in an ATP- and GTP-competitive...

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  • VEGFR-2 inhibitor

    Biovision | VEGFR-2 inhibitor | B2938

    VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at...

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  • ZXX2-77

    Biovision | ZXX2-77 | B2937

    ZXX2-77 is a benzenesulfonanilide derivative that inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. It shows more potent analgesic activity than aspirin at 30 mg/kg by po. It can be used as a...

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  • WAY-265497

    Biovision | WAY-265497 | B2936

    WAY-265497 is a potent ATP-binding site-targeting inhibitor of Cdk4/D1 kinase activity with an IC₅₀ of 30 nM. It inhibits HCT116 and MCF-7 cancer cells with IC₅₀ values of 0.73 and 0.88 µM,...

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  • CK2 inhibitor

    Biovision | CK2 inhibitor | B2935

    CK2 inhibitor selectively inhibits casein kinase 2 (CK2) with an IC₅₀ of 0.125 μM. CK2 is a potential protein kinase target for the development of antitumor, antiviral and anti-inflammatory drugs.CK2...

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  • ROCK-II Inhibitor

    Biovision | ROCK-II Inhibitor | B2934

    ROCK Inhibitor-II inhibits the Rho kinase ROCK-II with an IC₅₀ <1 nM. It inhibits the cell based Myosin Light Chain (MLC) bisphosphorylation with an IC₅₀ of 7 nM.ROCK Inhibitor-II inhibits the Rho...

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  • BRD6929

    Biovision | BRD6929 | B2931

    BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM...

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