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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • Reserpine

    Biovision | Reserpine | B2681

    Reserpine is an alkaloid isolated from dried roots of R. serpentine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectively). It also inhibits adrenaline induced-cutaneous...

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  • (S)-Duloxetine hydrochloride

    Biovision | (S)-Duloxetine hydrochloride | B2680

    (S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively). It is...

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  • Bambuterol Hydrochloride

    Biovision | Bambuterol Hydrochloride | B2679

    Bambuterol is a prodrug for terbutaline that acts as a long-acting β-adrenoceptor agonist. Bambuterol is converted to terbutaline by butyrylcholinesterases in the liver and plasma. Acts as a bronchodilator and anti-histamine agent.Bambuterol is a prodrug...

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  • Emtricitabine

    Biovision | Emtricitabine | B2678

    Emtricitabine is a cytidine analog that acts as an inhibitor of reverse transcriptase, preventing replication of HIV-1 (EC50 = 10-20 nM) and hepatitis B (EC50 = 10-40 nM). It is activated through multistep intracellular phosphorylation by various...

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  • Olanzapine

    Biovision | Olanzapine | B2677

    Olanzapine is an antipsychotic agent with anticholinergic properties. It binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57...

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  • iFSP1

    Biovision | iFSP1 | B2676

    iFSP1 inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. iFSP1 (3 μM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3 (Cat. No. B2303).iFSP1 inhibits ferroptosis...

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  • Dibromobimane

    Biovision | Dibromobimane | B2673

    Dibromobimane, a bifunctional thiol-reactive fluorescent reagent that is used as a cross-linking agent for cysteine mapping and studies on protein structure/conformation and cross-linking processes. It is a unique fluorogenic crosslinking reagent for...

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  • Monobromobimane

    Biovision | Monobromobimane | B2672

    Monobromobimane (mBBr) is a cell-permeable, thiol-reactive fluorescent probe that is widely used to detect various thiol-containing biomolecules such as glutathione in cells. It reacts rapidly at physiological pH with available thiol groups, and...

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  • Monochlorobimane

    Biovision | Monochlorobimane | B2671

    Monochlorobimane is a cell-permeant probe for quantifying glutathione levels in cells. It is essentially nonfluorescent until it reacts with a thiol group. It readily reacts with several low molecular weight thiols, including cysteine, glutathione,...

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  • Pemafibrate, Free Acid

    Biovision | Pemafibrate, Free Acid | B2670

    Pemafibrate free acid (K877) is a selective peroxisome proliferator-activated receptor-α (PPAR-α) modulator and a next-generation PPAR-α agonist. It activated PPAR-α, PPAR-γ, and PPAR-δ with EC₅₀ values of 1 nM, 2.3 µM, and 1 µM, respectively.Pemafibrate...

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  • CA-1001

    Biovision | CA-1001 | B2669

    CA-1001 is a neutral ionophore with high selectivity for Ca²⁺ ions. CA-1001 can be used in microelectrodes for the determination of intracellular Ca2+-activities and of slowly changing Ca²⁺ levels. Also useful for transport studies in biological...

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  • MI-463

    Biovision | MI-463 | B2668

    MI-463 is a potent inhibitor of Menin-MLL interaction (IC₅₀ = 15.3 nM). Pharmacologic inhibition of the menin-mLL interaction substantially delays progression of mLL leukemia in murine models through on-target activity without causing toxicity. MI-463...

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  • BAY-598

    Biovision | BAY-598 | B2667

    BAY-598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC₅₀ values are 27 and 58 nM for biochemical and cellular activity assays, respectively). It displays >100-fold selectivity for SMYD2 over a panel of 32 other...

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  • ML-216

    Biovision | ML-216 | B2666

    ML-216 is a potent and selective inhibitor of BLM (Bloom) helicase (IC₅₀ = 1.8 μM); it displays 28-fold selectivity against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently...

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  • NSC-19630

    Biovision | NSC-19630 | B2665

    NSC-19630 (MIRA-1) is a cell-permeable inhibitor of Werner syndrome WRN helicase activity (IC₅₀ = 20 µM) over its ATPase and exonuclease activities, but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1,...

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  • NSC-617145

    Biovision | NSC-617145 | B2664

    NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD...

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  • CDE-096

    Biovision | CDE-096 | B2663

    CDE-096 is a high affinity, synthetic inactivator of plasminogen activator inhibitor-1 (PAI-1). CDE-096 binds to PAI-1 with nanomolar affinity and induces conformational changes that prevent binding to both proteases and vitronectin. This allosteric...

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  • Dutasteride

    Biovision | Dutasteride | B2662

    Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT. Dutasteride blocks testosterone...

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  • Cytarabine

    Biovision | Cytarabine | B2661

    Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM,...

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  • Pirfenidone

    Biovision | Pirfenidone | B2660

    Pirfenidone is a small molecule antifibrotic agent. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary...

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  • 10-Deacetylbaccatin III

    Biovision | 10-Deacetylbaccatin III | B2659

    10-Deacetylbaccatin III is a precursor in the semisynthetic synthesis of paclitaxel; acts as an inhibitor of microtubule assembly (IC₅₀s = 23 and 0.9 µM for porcine brain and Physaram microtubules, respectively). 10-Deacetylbaccatin III also selectively...

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  • Carmustine

    Biovision | Carmustine | B2658

    Carmustine is a nitrogen mustard and a cell-cycle phase nonspecific alkylating antineoplastic agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit...

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  • Terbinafine hydrochloride

    Biovision | Terbinafine hydrochloride | B2657

    Terbinafine hydrochloride is a selective TASK3 (TWIK-related acid-sensitive K⁺ channel 3, KCNK9, K2P9.1) activator (pEC₅₀ = 6.2). It displays >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also acts...

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  • cADP-Ribose, ammonium salt

    Biovision | cADP-Ribose, ammonium salt | B2656

    Cyclic ADP-ribose (cADP-ribose) is potent calcium (Ca ²⁺) second messenger. This endogenous metabolite of NAD+ mobilizes the release of stored Ca²⁺ in the endoplasmic reticulum via ryanodine receptors in various cell types.yclic ADP-ribose (cADP-ribose)...

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  • Teniposide

    Biovision | Teniposide | B2655

    Teniposide is a podophyllotoxin derivative that acts as a topoisomerase II inhibitor. Its cytostatic effects are related to its ability to stabilize the DNA-topoisomerase II complex during DNA replication, inducing DNA damage and cellular apoptosis...

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  • Methotrexate

    Biovision | Methotrexate | B2654

    Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to...

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  • Ifosfamide

    Biovision | Ifosfamide | B2653

    Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. Like cyclophosphamide, ifosfamide serves as a prodrug that...

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  • Estramustine phosphate sodium

    Biovision | Estramustine phosphate sodium | B2652

    Estramustine phosphate sodium is a nitrogen mustard linked to estradiol that acts as a microtubule assembly inhibitor. Inhibits endothelial cell proliferation (IC₅₀ = 4.5 μM) and down-regulates prostate-specific antigen expression (IC₅₀ = 10.97 μM)...

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  • Eflornithine

    Biovision | Eflornithine | B2651

    Eflornithine (Difluoromethylornithine) is a fluorinated ornithine analog that acts as an irreversible inhibitor of ornithine decarboxylase (ODC). It displays antiangiogenic activity, inhibits carcinogenesis, and induces apoptosis. Eflornithine functions...

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  • Doxifluridine

    Biovision | Doxifluridine | B2650

    Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase...

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  • Deferasirox

    Biovision | Deferasirox | B2649

    Deferasirox is an orally bioavailable tridentate iron chelator. It is selective for iron (Fe(III)) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III). Deferasirox decreases iron levels in iron-loaded rat heart cells in vitro by 45.8 and 55...

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  • Fotemustine

    Biovision | Fotemustine | B2648

    Fotemustine is a third generation nitrosourea, chloroethylating agent with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages,...

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  • XMD8-87

    Biovision | XMD8-87 | B2647

    XMD8-87 is a potent Ack1/TNK2 inhibitor (IC₅₀ = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). XMD8-87 potently inhibits phosphorylation of TNK2 truncation mutations found in solid tumor types...

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  • WAY-316606

    Biovision | WAY-316606 | B2646

    WAY-316606 is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM). It blocks sFRP-1 from interacting with Wnt and thus increases Wnt signaling.WAY-316606 is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC₅₀ = 0.65 μM)...

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  • i-CRT3

    Biovision | i-CRT3 | B2645

    i-CRT3 is a small cell-permeable oxazole derivative that acts as an inhibitor of both Wnt and β-catenin-responsive transcription.i-CRT3 is a small cell-permeable oxazole derivative that acts as an inhibitor of both Wnt and β-catenin-responsive...

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  • LF3

    Biovision | LF3 | B2644

    LF3 is a potent inhibitor of canonical Wnt signaling pathway (IC₅₀ < 2 µM ). It can disrupt the interaction between catenin and TCF4. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation...

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  • NCB-0846

    Biovision | NCB-0846 | B2643

    NCB-0846 is a potent small-molecule TNIK (Traf2 and Nck-interacting protein kinase) inhibitor, having anti-Wnt activity and suppressing Wnt-driven intestinal tumorigenesis. Also inhibits FLT3, JAK3, PDGFRa, TRKA, CDK2/CycA2, and HGK. NCB-0846 suppresses...

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  • Hydroxy Dynasore

    Biovision | Hydroxy Dynasore | B2642

    Hydroxy Dynasore is an analog of Dynasore (Cat. No. 1900) that acts as a potent dynamin inhibitor (IC₅₀ values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic...

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  • LDN-212854

    Biovision | LDN-212854 | B2641

    LDN-212854 is a potent ALK inhibitor (IC₅₀ values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Displays selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Also exhibits activity against RIPK2, ABL1...

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  • Atovaquone

    Biovision | Atovaquone | B2640

    Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently...

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  • DSM265

    Biovision | DSM265 | B2639

    DSM265 is a potent, selective and long duration dihydroorotate dehydrogenase (DHODH)) inhibitor (IC₅₀ = 8.9 nM). DSM265 is potential useful for the prevention and treatment of malaria. DSM265 is highly selective towards DHODH of the malaria parasite...

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  • Rogaratinib

    Biovision | Rogaratinib | B2638

    Rogaratinib (BAY-1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.Rogaratinib (BAY-1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor.Biovision | B2638 | Rogaratinib...

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  • Brequinar Sodium

    Biovision | Brequinar Sodium | B2637

    Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Blocks de novo pyrimidine biosynthesis. Displays minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines...

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  • NMS-1286937

    Biovision | NMS-1286937 | B2636

    NMS-1286937 a potent, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC₅₀ = 2 nM) with potential antineoplastic activity. It selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells...

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  • DAPPD

    Biovision | DAPPD | B2635

    DAPPD is an antineuroinflammatory agent. DAPPD regulates microglial function, suppresses neuroinflammation, fosters cerebral Aβ clearance, and attenuates cognitive deficits in AD transgenic mouse models.DAPPD is an antineuroinflammatory agent. DAPPD...

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  • PF-3758309

    Biovision | PF-3758309 | B2634

    PF-3758309 is a potent small molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the...

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  • ML-228

    Biovision | ML-228 | B2633

    ML-228 is an activator of the Hypoxia Inducible Factor (HIF) signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 µM), HIF-1α nuclear translocation assay (EC50 = 1.3 µM), and increased VEGF expression (EC50 = 1.6...

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  • Dimedone

    Biovision | Dimedone | B2632

    Dimedone displays many biological properties such as anticarcinogenic, antioxidant, antihistaminic, and anticoagulant.Dimedone displays many biological properties such as anticarcinogenic, antioxidant, antihistaminic, and anticoagulant.Biovision | B2632...

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  • Ruxolitinib phosphate

    Biovision | Ruxolitinib phosphate | B2631

    Ruxolitinib phosphate is the phosphate salt form of ruxolitinib, a potent Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1...

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  • EZSolution™ PF-04217903

    Biovision | EZSolution™ PF-04217903 | B2628

    A 10 mM (5 mg in 1.34 ml) of the ATP-competitive c-Met kinase inhibitor (Cat. No. B2062) in anhydrous DMSOA 10 mM (5 mg in 1.34 ml) of the ATP-competitive c-Met kinase inhibitor (Cat. No. B2062) in anhydrous DMSOBiovision | B2628 | EZSolution™...

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