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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • GSK-2190915 sodium salt

    Biovision | GSK-2190915 sodium salt | B2518

    GSK-2190915 sodium is a potent and selective FLAP (5-Lipoxygenase-activating protein) inhibitor (IC₅₀ of 2.6 nM); displays good selectivity over CYP3A4, 2C9, and 2D6. In an acute inflammation setting, GSK-2190915 dose-dependently reduces LTB4, CysLTs,...

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  • MK-886

    Biovision | MK-886 | B2517

    MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5 nM). MK-886 also inhibits cyclooxygenase-1 (COX-1)...

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  • SPHINX31

    Biovision | SPHINX31 | B2516

    SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) IC₅₀ = 5.9 nM). It displays selectivity for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing...

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  • PFK-158

    Biovision | PFK-158 | B2515

    PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC₅₀ = 137 nM for human recombinant PFKFB3). Upon administration, PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the...

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  • CH7057288

    Biovision | CH7057288 | B2514

    CH7057288 as a potent and selective TRK (tropomyosin receptor kinase) inhibitor that may be useful in inhibiting TRK fusion-positive cancer cell growth. CH7057288 shows selective inhibitory activity against TRKA, TRKB, and TRKC in cell-free kinase assays...

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  • AZD-3229

    Biovision | AZD-3229 | B2513

    AZD3229 is a potent, pan-KIT mutant inhibitor that displays single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V). Potentially...

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  • Zanubrutinib

    Biovision | Zanubrutinib | B2512

    Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; displaysmuch more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib. BGB-3111 selectively binds to and inhibits the...

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  • PLX-51107

    Biovision | PLX-51107 | B2511

    PLX-51107 is a potent inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, PLX51107 binds to the acetylated lysine recognition motifs in the bromodomains of the BRD4 protein, thereby...

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  • SAR-125844

    Biovision | SAR-125844 | B2510

    SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous administration, SAR-125844 binds to c-Met, thereby disrupting...

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  • CPI-1205

    Biovision | CPI-1205 | B2509

    CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ = 0.032 μM). Upon oral administration, CPI-1205...

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  • MEDICA 16

    Biovision | MEDICA 16 | B2508

    MEDICA 16 is a GPR40 agonist; displays selectivity for FFA1 (GPR40) over GPR120. Exhibits hypolipidemic and antidiabetogenic effects in the rat. Also inhibits ATP citrate lyase.MEDICA 16 is a GPR40 agonist; displays selectivity for FFA1 (GPR40) over...

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  • SB-204490

    Biovision | SB-204490 | B2507

    SB-204490 is a potent and specific ATP citrate lyase (ACLY) inhibitor. Prodrug of SB-201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells.SB-204490 is a potent and specific ATP citrate lyase (ACLY) inhibitor...

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  • Namodenoson

    Biovision | Namodenoson | B2506

    Namodenoson (CF-102) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectivelyNamodenoson (CF-102) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays...

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  • CEP-40783

    Biovision | CEP-40783 | B2505

    CEP-40783 (RDX-106) is a potent and selective inhibitor of AXL and c-Met with IC₅₀ values of 7 nM and 12 nM, respectively. In AXL-transfected 293GT cells, CEP-40783 was 27-fold more active compared to recombinant enzyme with an IC50 value of 0.26 nM...

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  • CEP-37440

    Biovision | CEP-37440 | B2504

    CEP-37440 is a potent and selective dual FAK/ALK inhibitor with IC₅₀ s of 2.3 nM (FAK) and 120 nM (ALK cellular IC₅₀ in 75% human plasma). The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits...

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  • CEP-28122

    Biovision | CEP-28122 | B2503

    CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). Displays antitumor activity in experimental models of human cancers.CEP-28122 is a highly potent and selective orally active inhibitor...

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  • CCT-251921

    Biovision | CCT-251921 | B2502

    CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated...

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  • CCT-251545

    Biovision | CCT-251545 | B2501

    CCT-251545 is a potent Wnt signaling inhibitor (IC₅₀ = 5 nM). It is a selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT-251545 alters Wnt pathway-regulated gene...

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  • CCT-196969

    Biovision | CCT-196969 | B2500

    CCT-196969 is a pan-Raf inhibitor, which inhibits B-Raf, BRafV600E and CRAF with IC₅₀s of 0.1, 0.04, and 0.01 μM, respectively. It is selective for RAFs, Src, LCK, and MAPKs in a panel of 63 kinases when used at a concentration of 1 μM. CCT-196969...

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  • CC-115

    Biovision | CC-115 | B2499

    CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and displays effective reduction of murine PC3 tumor xenografts.CC-115 is a potent dual inhibitor of...

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  • XMU-MP-1

    Biovision | XMU-MP-1 | B2498

    XMU-MP-1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC₅₀ values are 38.1 and 71.1 nM for MST2 and MST1, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1...

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  • DIM-C-pPhCO2Me

    Biovision | DIM-C-pPhCO2Me | B2497

    DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist that displays antineoplastic activity.DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist that displays antineoplastic activity.Biovision | B2497 | DIM-C-pPhCO2Me DataSheetAlternate...

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  • IDO-IN-2

    Biovision | IDO-IN-2 | B2496

    IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 0.068 µM).IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 0.068 µM).Biovision | B2496 | IDO-IN-2 DataSheetAlternate Name/Synonyms:...

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  • 4μ8C

    Biovision | 4μ8C | B2495

    4µ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). It blocks substrate access to the active site of IRE1α and inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L...

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  • CAY10566

    Biovision | CAY10566 | B2494

    CAY10566 is a potent and selective stearoyl-CoA desaturase (SCD) inhibitor (IC₅₀ values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.CAY10566 is a potent and selective stearoyl-CoA desaturase (SCD) inhibitor (IC₅₀ values of 4.5 and...

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  • Marizomib

    Biovision | Marizomib | B2493

    Marizomib (Salinosporamide A) is a potent, reversible, broad-spectrum, brain-penetrant proteasome inhibitor, that displays antitumor activity in vitro and in vivo.Marizomib (Salinosporamide A) is a potent, reversible, broad-spectrum, brain-penetrant...

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  • EZSolution™ Carfilzomib

    Biovision | EZSolution™ Carfilzomib | B2491

    A 10 mM (5 mg in 695 µl) of the potent proteasome inhibitor Carfilzomib (Cat. No. 2385) in anhydrous DMSO.Carfilzomib (PR-171) is a next generation, irreversible and selective inhibitor of the chymotrypsin-like activity of the proteasome. It displays...

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  • EZSolution™ Cobimetinib

    Biovision | EZSolution™ Cobimetinib | B2489

    A 10 mM (5 mg in 941 µl) of the potent MEK inhibitor Cobimetinib (Cat. No. B1689) in anhydrous DMSO.Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).Biovision | B2489 | EZSolution™...

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  • EZSolution™ Ixazomib

    Biovision | EZSolution™ Ixazomib | B2488

    A 10 mM (5 mg in 1.38 ml) of the potent proteasome inhibitor Ixazomib (Cat. No. B2384) in anhydrous DMSO.Ixazomib (MLN-2238), is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL-2238 is a biologically active form of MLN9708...

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  • EZSolution™ Pacritinib

    Biovision | EZSolution™ Pacritinib | B2485

    A 10 mM (1 mg in 212 µl) of the potent JAK2/FLT3 inhibitor Pacritinib (SB1518) (Cat. No. 2450) in anhydrous DMSO.A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM) and FLT3 (IC₅₀ = 22 nM). SB1518 displays potent...

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  • EZSolution™ Cyt387

    Biovision | EZSolution™ Cyt387 | B2484

    A 10 mM (5 mg in 1.21 ml) of the JAK1 and JAK2 inhibitor Cyt387 (Momelotinib) (Cat. No. 2316) in anhydrous DMSO.Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and 18 nM, respectively. Inhibits JAK3 at much higher...

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  • EZSolution™ LY-2784544

    Biovision | EZSolution™ LY-2784544 | B2483

    A 10 mM (5 mg in 1064 µl) solution of the potent JAK2 inhibitor LY-2784544 (Gandotinib) (Cat. No. B1914) in anhydrous DMSO.LY2784544 (Gandotinib) is a potent, selective and ATP-competitive JAK2 inhibitor (IC₅₀ = 3 nM). effective in JAK2V617F, 8- and...

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  • EZSolution™ Cerdulatinib

    Biovision | EZSolution™ Cerdulatinib | B2482

    A 10 mM (5 mg in 1.12 ml) solution of the potent Syk and JAK inhibitor Cerdulatinib (Cat. No. 2803) in anhydrous DMSO.Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. It preferentially inhibits JAK1 and JAK3...

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  • EZSolution™ Filgotinib

    Biovision | EZSolution™ Filgotinib | B2481

    A 10 mM (5 mg in 1.18 ml) solution of the potent JAK1 inhibitor Filgotinib (Cat. No. 2871) in anhydrous DMSO.Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently...

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  • EZSolution™ Baricitinib

    Biovision | EZSolution™ Baricitinib | B2480

    A 10 mM (5 mg in 1.35 ml) of the JAK1 and JAK2 inhibitor Baricitinib (Cat. No. 2842) in anhydrous DMSO.Baricitinib is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective...

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  • EZSolution™ PF-03394197

    Biovision | EZSolution™ PF-03394197 | B2479

    A 10 mM (5 mg in 1.48 ml) solution of the JAK inhibitor PF-03394197 (Oclacitinib) in anhydrous DMSO.PF-03394197 (Oclacitinib) is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK family members with an IC₅₀ of 10-99 nM being most potent...

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  • EZSolution™ CP-690550

    Biovision | EZSolution™ CP-690550 | B2478

    A 10 mM (5 mg in 1.60 ml) solution of the potent JAK3 inhibitor CP-690550 (Cat. No. 1622) in anhydrous DMSO.A Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell...

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  • EZSolution™ Ruxolitinib

    Biovision | EZSolution™ Ruxolitinib | B2477

    A 10 mM (5 mg in 1.63 ml) solution of the potent JAK inhibitor Ruxolitinib (Cat. No. 2139) in anhydrous DMSO.Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with IC₅₀'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays...

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  • Oosporein

    Biovision | Oosporein | B2476

    Oosporein is a di-symmetric cyclohexadienedione produced by several species of fungi. Displays toxic effects on humans as well as animal health. Also acts as an ATPase inhibitor.Oosporein is a di-symmetric cyclohexadienedione produced by several species...

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  • CHZ868

    Biovision | CHZ868 | B2475

    CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces...

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  • Peficitinib

    Biovision | Peficitinib | B2474

    Peficitinib is a potent JAK inhibitor, with IC₅₀s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC₅₀ = 10 nM) and phosphorylation of STAT5 in rat and human...

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  • CEP-33779

    Biovision | CEP-33779 | B2473

    CEP-33779 is a potent and orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It displays 65-fold selectivity for JAK2 over JAK3. CEP-33779 induces regression of established colorectal tumors, reduces angiogenesis, and reduces proliferation of tumor...

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  • Alvimopan

    Biovision | Alvimopan | B2472

    Alvimopan is a peripherally acting μ-opioid receptor antagonist (Ki = 0.47 nM) that is selective over the κ- and δ-opioid receptors (Ki's = 100 nM and 12 nM, respectively). It is used to avoid postoperative ileus following small or large bowel resection...

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  • dBET6

    Biovision | dBET6 | B2471

    dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC₅₀ of 14 nM. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition. Displays antitumor activity.dBET6 is a highly potent, selective...

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  • PF-04965842

    Biovision | PF-04965842 | B2470

    PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1 inhibitor (IC₅₀ = 29 nM). It displays excellent selectivity for JAK1 versus other JAK family enzymes.PF-04965842 (Abrocitinib) is a potent, selective, orally bioavailable JAK1...

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  • Reparixin

    Biovision | Reparixin | B2469

    Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC₅₀s of 1 and 100 nM, respectively. Blocks a range of activities including leukocyte recruitment and IL-8 signaling.Reparixin is a...

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  • PF-3084014

    Biovision | PF-3084014 | B2468

    PF-3084014 (Nirogacestat) is a potent and selective gamma-secretase inhibitor (IC₅₀ of 6.2 nM). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.PF-3084014 (Nirogacestat) is a potent and selective gamma-secretase inhibitor (IC₅₀ of 6.2 nM)...

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  • PF-04449913

    Biovision | PF-04449913 | B2467

    PF-04449913 is a potent and orally bioavailable smoothened (SMO) inhibitor. PF-04449913 binds to human SMO with an IC₅₀ of 4 nM. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia...

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  • Sulfatinib

    Biovision | Sulfatinib | B2466

    Sulfatinib is a potent, orally bioavailable and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC₅₀s of in a range of 1 to 24 nM.Sulfatinib is a potent, orally bioavailable and highly selective tyrosine kinase...

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