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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • 8-Azaadenosine

    Biovision | 8-Azaadenosine | B2572

    8-Azaadenosine is an ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor. Reduces A-to-I editing activity in a leukemia cell line, restores let-7 and inhibits leukemia stem cells self-renewal in vitro. Acts as an inhibitor of ovarian...

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  • AZ-304

    Biovision | AZ-304 | B2571

    AZ-304 is a potent, ATP-competitive dual BRAF kinase inhibitor that inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. In addition, AZ-304 exhibits significant effect on other kinases such...

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  • ARN-272

    Biovision | ARN-272 | B2570

    ARN-272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC₅₀ = 1.8 µM). It attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Displays analgesic effects in rodent models of CB1-mediated nociceptive and...

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  • AM-92016 Hydrochloride

    Biovision | AM-92016 Hydrochloride | B2569

    AM-92016 hydrochloride is a specific inhibitor of delayed rectifier potassium current. In guinea-pig and rabbit ventricular cells, AM 92016 significantly increased action potential duration with 20% and 90% repolarization levels, respectively. Also,...

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  • Atractylenolide I

    Biovision | Atractylenolide I | B2568

    Atractylenolide I is a sesquiterpene that displays diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as...

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  • Riviciclib hydrochloride

    Biovision | Riviciclib hydrochloride | B2567

    Riviciclib hydrochloride is a potent cyclin dependent kinase (CDK) inhibitor (IC₅₀ values of 79 nM, 63 nM and 20 nM for CDK1, CDK4 and CDK9, respectively). Displays potential antineoplastic activity.Riviciclib hydrochloride is a potent cyclin dependent...

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  • Sardomozide Hydrochloride

    Biovision | Sardomozide Hydrochloride | B2566

    Sardomozide Hydrochloride is a second-generation polyamine synthesis inhibitor, that inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). Sardomozide is more potent and specific than the first-generation...

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  • TTP-22

    Biovision | TTP-22 | B2565

    TTP-22 is a potent casein kinase 2 (CK2) inhibitor with an IC₅₀ value of 100 nM (Ki = 40 nM). It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases even at 10 μM.TTP-22 is a potent casein kinase 2...

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  • BAY-8002

    Biovision | BAY-8002 | B2564

    BAY-8002 is a potent dual MCT1/2 (Monocarboxylate Transporter ½) inhibitor. Inhibits cellular SNARF-5 fluorescence change (IC₅₀ = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in...

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  • V-9302

    Biovision | V-9302 | B2563

    V-9302 is a competitive antagonist of transmembrane glutamine flux, that selectively targets the amino acid transporter ASCT2 (SLC1A5). V-9302 inhibits ASCT2-mediated glutamine uptake (IC₅₀ = 9.6 µM) in HEK-293 cells.V-9302 is a competitive antagonist of...

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  • iCRT14

    Biovision | iCRT14 | B2562

    iCRT14 is a potent potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC₅₀ = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter...

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  • Glumetinib

    Biovision | Glumetinib | B2561

    Glumetinib (SCC-244) is a potent and highly selective inhibitor of c-Met kinase (IC₅₀ = 0.42 nM). Glumetinib displays subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases.Glumetinib (SCC-244) is...

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  • Robenidine hydrochloride

    Biovision | Robenidine hydrochloride | B2560

    Robenidine hydrochloride is an antibiotic used as an effective anticoccidial. It does not affect the earliest stages in the coccidial life-cycle and its main activity is against the almost mature first generation schizont. It is used as an aid in the...

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  • GW-311616A

    Biovision | GW-311616A | B2559

    GW-311616 hydrochloride is a potent and selective intracellular neutrophil elastase (NE, α-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for...

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  • AMG-510

    Biovision | AMG-510 | B2558

    AMG-510 is an orally available agent that targets the specific KRAS mutation, p.G12C, with potential antineoplastic activity. Upon oral administration, KRAS mutant-targeting AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or...

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  • (+)-cis-Diltiazem hydrochloride

    Biovision | (+)-cis-Diltiazem hydrochloride | B2557

    (+)-cis-Diltiazem hydrochloride is an antihypertensive and cardioprotective agent and an inhibitor of L-type Ca²⁺ channels.(+)-cis-Diltiazem hydrochloride is an antihypertensive and cardioprotective agent and an inhibitor of L-type Ca²⁺ channels...

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  • Tirabrutinib hydrochloride

    Biovision | Tirabrutinib hydrochloride | B2556

    Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton’s Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.Tirabrutinib...

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  • Vesatolimod

    Biovision | Vesatolimod | B2555

    Vesatolimod (GS-9620) is a potent Toll-like receptor-7 (TLR-7) agonist which has been developed as an anti-hepatitis B virus (HBV) agent.Vesatolimod (GS-9620) is a potent Toll-like receptor-7 (TLR-7) agonist which has been developed as an anti-hepatitis...

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  • CB-1158 dihydrochloride

    Biovision | CB-1158 dihydrochloride | B2554

    CB-1158 dihydrochloride (INCB01158 dihydrochloride) is a potent nhibitor of arginase, with IC₅₀s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively.CB-1158 dihydrochloride (INCB01158 dihydrochloride) is a potent nhibitor of arginase,...

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  • Dabigatran Etexilate

    Biovision | Dabigatran Etexilate | B2552

    Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as thrombin-induced platelet aggregation (IC50 = 10 nM), while showing...

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  • L-Propargylglycine

    Biovision | L-Propargylglycine | B2551

    L-Propargylglycine (PAG) is an inhibitor of cystathionine γ-lyase (CSE). Cystathionine γ-lyase catalyzes H2S synthesis and is a potential target for modulating H2S levels under pathophysiological conditions. L-propargylglycine is useful in studies of...

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  • nor-NOHA acetate

    Biovision | nor-NOHA acetate | B2550

    nor-NOHA acetate is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA. Nor-NOHA is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse...

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  • PF-04620110

    Biovision | PF-04620110 | B2549

    PF-04620110 is a potent and selective Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) inhibitor with (IC₅₀ = 19 nM).PF-04620110 is a potent and selective Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) inhibitor with (IC₅₀ = 19 nM).Biovision |...

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  • BLU-667 (Pralsetinib)

    Biovision | BLU-667 (Pralsetinib) | B2548

    BLU-667 (Pralsetinib) is a highly potent and selective, next generation RET inhibitor with IC₅₀ of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. In vivo, BLU-667 potently inhibits growth of NSCLC and thyroid cancer...

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  • RU-521

    Biovision | RU-521 | B2547

    RU-521 (RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM). RU-521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in...

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  • KKL-35

    Biovision | KKL-35 | B2546

    KKL-35 is a potent trans-translation inhibitor that displays broad-spectrum antibiotic activity. KKL-35 inhibits trans-translation, and subsequent cell growth in a broad spectrum of bacterial strains.KKL-35 is a potent trans-translation inhibitor that...

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  • LOXO-101 sulfate

    Biovision | LOXO-101 sulfate | B2545

    LOXO-101 is a potent, ATP-competitive TRK inhibitor with IC₅₀s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100-fold selectivity over other kinases, with 2 to 20 nM cellular potency against the...

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  • CBR-5884

    Biovision | CBR-5884 | B2543

    CBR-5884 is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 33 μM) inhibiting serine synthesis from 3-phosphoglycerate in cells. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other...

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  • SBI-115

    Biovision | SBI-115 | B2542

    SBI-115 is a potent TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.SBI-115 is a potent TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases...

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  • CY-09

    Biovision | CY-09 | B2541

    CY-09 is a potent and specific NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation.CY-09 is a potent and specific NLRP3 inhibitor (Kd = 500 nM); directly binds to...

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  • Glesatinib

    Biovision | Glesatinib | B2540

    Glesatinib is a potent multitargeted tyrosine kinase inhibitor. It binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular...

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  • Sitravatinib

    Biovision | Sitravatinib | B2539

    Sitravatinib (MGCD516; MG516) is a potent receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT , FLT3, DDR2, DDR1, TRKA, TRKB,...

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  • USP7/USP47 Inhibitor

    Biovision | USP7/USP47 Inhibitor | B2538

    USP7/USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC₅₀s = 0.42 and 1 μM, respectively). It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC₅₀s = >31.6 μM)...

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  • Massonianoside B

    Biovision | Massonianoside B | B2537

    Massonianoside B (MA) is a structurally unique natural product inhibitor of DOT1L with an IC50 value of 399 nM. It displays high selectivity for DOT1L over other S-adenosylmethionine (SAM)-dependent PMTs (Protein methyltransferases).Massonianoside B (MA)...

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  • Fadrozole

    Biovision | Fadrozole | B2536

    Fadrozole is a potent, nonsteroidal aromatase inhibitor with potential antineoplastic activity. Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, the final...

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  • Cabotegravir

    Biovision | Cabotegravir | B2535

    Cabotegravir is a long acting HIV-1 integrase inhibitor that displays activity against a broad range of HIV subtypes.Cabotegravir is a long acting HIV-1 integrase inhibitor that displays activity against a broad range of HIV subtypes.Biovision | B2535 |...

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  • Balovaptan

    Biovision | Balovaptan | B2534

    Balovaptan is a potent and selective vasopressin-1 receptor antagonistBalovaptan is a potent and selective vasopressin-1 receptor antagonistBiovision | B2534 | Balovaptan DataSheetAlternate Name/Synonyms: RG-7314;...

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  • GNE-272

    Biovision | GNE-272 | B2533

    GNE-272 is a potent and selective in vivo probe for the bromodomains of CBP/EP300 (IC₅₀ values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively). Displays marked antiproliferative effect in hematologic cancer cell lines.GNE-272 is a potent...

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  • Muramyl Dipeptide

    Biovision | Muramyl Dipeptide | B2532

    Muramyl dipeptide is a synthetic immunoreactive peptide that activates NOD2 receptors. Induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes. Also inhibits HIV replication in CD4⁺ H9 lymphocytes.Muramyl dipeptide is a...

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  • CP-424174

    Biovision | CP-424174 | B2531

    CP-424,174 is a cytokine release inhibitory drug (CRID) that inhibits the post-translational processing and secretion of IL-1β in response to LPS and ATP in human monocytes. Also indirectly inhibits NLRP3.CP-424,174 is a cytokine release inhibitory drug...

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  • EZSolution™ INF39

    Biovision | EZSolution™ INF39 | B2530

    INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. It inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells.INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. It inhibits IL-1β release, caspase activation and pyroptosis...

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  • NLRP3i

    Biovision | NLRP3i | B2529

    NLRP3i is an intermediate in the glyburide synthesis that acts as a NLRP3 inflammasome inhibitor. It inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size after myocardial ischemia-reperfusion in the mouse,...

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  • STF-083010

    Biovision | STF-083010 | B2528

    STF-083010 is a potent Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. It blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+...

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  • Ac-IEPD-AFC

    Biovision | Ac-IEPD-AFC | B2526

    Ac-IEPD-AFC is a useful fluorogenic substrate for the detection of Granzyme B. Granzyme B activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at 400 nm and emission maximum at 505 nm.Ac-IEPD-AFC is a useful...

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  • Clemastine Fumarate

    Biovision | Clemastine Fumarate | B2525

    Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM); also displays high affinity for muscarinic receptors (Ki = 16 nM). Also acts as a positive allosteric modulator of P2X7 receptor signaling. Clinically-used as an...

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  • LTURM-34

    Biovision | LTURM-34 | B2524

    LTURM-34 is a potent DNA-PK inhibitor (IC₅₀ = 34 nM). Displays 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.LTURM-34 is a potent DNA-PK inhibitor (IC₅₀ = 34 nM). Displays 170-fold...

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  • PP121

    Biovision | PP121 | B2523

    PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits both tyrosine kinases and PI3-Ks but not serine-threonine kinases. It potently inhibits p110α, p110β, p110γ, p110δ, DNA-PK and mTOR with IC50 values of 52nM, 1.4μM, 1.1μM,...

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  • NU-7026

    Biovision | NU-7026 | B2522

    NU-7026 is a potent DNA-PK inhibitor (IC₅₀ of 0.23 μM); displays 60-fold selectivity for DNA-PK than PI3K and inactive against both ATM and ATR.NU-7026 is a potent DNA-PK inhibitor (IC₅₀ of 0.23 μM); displays 60-fold selectivity for DNA-PK than PI3K and...

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  • AM-679

    Biovision | AM-679 | B2521

    AM-679 is a potent 5-lipoxygenase-activating protein (FLAP) inhibitor with IC₅₀s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.AM-679 is a potent 5-lipoxygenase-activating protein (FLAP) inhibitor with IC₅₀s of 2.2 nM/0.6 nM/154 nM for...

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  • MK-591, Free acid

    Biovision | MK-591, Free acid | B2520

    MK-0591 is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs; potently...

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  • MK-591 sodium salt

    Biovision | MK-591 sodium salt | B2519

    MK-0591 sodium is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs;...

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