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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • Methylstat (hydrate)

    Biovision | Methylstat (hydrate) | B2836

    Methylstat is a methyl ester prodrug that inhibits Jumonji C domain-containing histone demethylase (JMJD) in cells. Methylstat inhibits growth of JMJD2C-sensitive oesophageal carcinoma cell line KYSE150 cells with an IC₅₀ of approximately 5.1 μM, whereas...

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  • TZ9

    Biovision | TZ9 | B2835

    TZ9 is a triazine analogue inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B/HHR6B. It docks to the Rad6B catalytic site. It inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and...

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  • 2-Hexyl-4-Pentynoic Acid

    Biovision | 2-Hexyl-4-Pentynoic Acid | B2834

    2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for Valproic acid. It induces histone hyperacetylation at a...

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  • MPI-5a

    Biovision | MPI-5a | B2833

    MPI-5a is a potent and selective inhibitor of Histone Deacetylase 6 (HDAC6) with an IC₅₀ of 36 nM. It inhibits the acetylation of tubulin in cells with an IC₅₀ value of 210 nM.MPI-5a is a potent and selective inhibitor of Histone Deacetylase 6 (HDAC6)...

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  • HPOB

    Biovision | HPOB | B2832

    HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human...

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  • TCS HDAC6 20b

    Biovision | TCS HDAC6 20b | B2831

    TCS HDAC6 20b is an inhibitor of histone deacetylase 6 (HDAC6). It synergistically inhibits the growth of HCT116 cells at a concentration of 5 µM in combination with paclitaxel. It blocks the growth of estrogen receptor α-positive breast cancer MCF-7...

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  • JFD00244

    Biovision | JFD00244 | B2830

    JFD00244 is an inhibitor of SIRT2. SIRT2 is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. A major substrate of SIRT2 is α-tubulin. JFD00244 inhibits SIRT2 with an IC₅₀ of 56.7 µM. It induces granulocytic differentiation in the acute...

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  • (±)-β-Hydroxybutyrate

    Biovision | (±)-β-Hydroxybutyrate | B2829

    (±)-β-Hydroxybutyrate is a ketone body which accumulates in blood during fasting when the liver switches to fatty acid oxidation or in Diabetic Ketoacidosis. It is an inhibitor of class I histone deacetylases (HDACs). It increases global histone...

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  • OAC3

    Biovision | OAC3 | B2828

    OAC3 (Oct4-activating compound3) is an activator of octamer-binding transcription factor 4 (Oct4). Oct4 is an important regulator of embryonic stem cells pluripotency. It is used to generate induced pluripotent stem cells (iPSCs) with the transcription...

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  • Iberin

    Biovision | Iberin | B2827

    Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and glutathione S-transferase (GST). It activates Nrf2 regulated...

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  • 5-Nitroso-8-quinolinol

    Biovision | 5-Nitroso-8-quinolinol | B2825

    5-Nitroso-8-quinolinol is a quinoline inhibitor of histone deacetylase (HDAC). It inhibits HDAC activity in vitro and causes reactive oxygen species, DNA damage and apoptosis in MCF-7 breast cancer cells at a concentration of 10 μM. It exhibits...

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  • Sinefungin

    Biovision | Sinefungin | B2824

    Sinefungin is a natural nucleoside and a structural analog of S-adenosylmethionine (SAM). It inhibits SAM-dependent nucleic acid methyltransferases and exhibits antifungal, antiviral, and antiprotozoal properties. It is a non-selective inhibitor of SET...

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  • UNC0224

    Biovision | UNC0224 | B2823

    UNC0224 is a selective G9a Histone Methyltransferase inhibitor. G9a methylates Histone H3 lysine 9, which is required for early embryogenesis. UNC0224 inhibits G9a with an IC₅₀ of 15 nM. It also inhibits GLP, another H3K9 methyltransferase with an IC₅₀...

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  • HNHA

    Biovision | HNHA | B2821

    HNHA is an inhibitor of Histone deacetylase (HDAC). It inhibited proliferation of HT1080 human fibrosarcoma cells with an IC₅₀ of 7.5 μM. It induced hyperacetylation, upregulation of p21 transcription and cell cycle arrest. It inhibited the growth of...

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  • KD 5170

    Biovision | KD 5170 | B2820

    KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro. KD5170 induced apoptosis in a broad range of human...

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  • CAY10603

    Biovision | CAY10603 | B2819

    CAY10603 is a selective inhibitor of Histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of HDAC6 is 2 pM, in vitro. CAY10603 inhibited growth of various pancreatic cell lines with IC₅₀ values ranging from 0.1 μM to 1 μM. It induced apoptosis and...

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  • Tenovin-6

    Biovision | Tenovin-6 | B2818

    Tenovin-6 is a SirT2 inhibitor and a p53 activator. It is a water-soluble analog of Tenovin-1. Tenovins inhibit the protein-deacetylase activities of SirT1 and SirT2. The IC₅₀ for inhibiting human SirT1 and SirT2 peptide deacetylase activity is 21 μM and...

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  • Butyrolactone 3

    Biovision | Butyrolactone 3 | B2817

    Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It...

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  • MI-nc (hydrochloride)

    Biovision | MI-nc (hydrochloride) | B2816

    MI-nc (hydrochloride) is a weak inhibitor of the menin-MLL interaction. Menin is a tumor suppressor protein. Menin is a part of the MLL (Mixed Lineage Leukemia) SET1-like histone methyl transferase complex. Association of menin with MLL fusion proteins...

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  • CPTH2 (hydrochloride)

    Biovision | CPTH2 (hydrochloride) | B2815

    CPTH2 (hydrochloride) is an inhibitor of Histone Acetyltransferase (HAT) activity of Gcn5. Gcn5 acetylates histones H2B and H3. CPTH2 inhibited HAT reaction in vitro and it decreased acetylation of histone H3 at the specific H3-K14 site at micromolar...

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  • GSK-J2 (Sodium Salt)

    Biovision | GSK-J2 (Sodium Salt) | B2813

    GSK-J2 (sodium salt) is an isomer of GSK-J1. GSK-1 is a selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX, with an IC₅₀ of 60 nM for human JMJD3 in vitro. GSK-J2 poorly inhibits JMJD3 with an IC₅₀ > 100 μM in vitro. GSK-J2 serves as a...

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  • Wedelolactone

    Biovision | Wedelolactone | B2811

    Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from NF-κB leading to NF-κB activation. Wedelolactone has...

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  • BRD9539

    Biovision | BRD9539 | B2810

    BRD9539 is a specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2). EHMT2 catalyzes the methylation of lysine 9 on histone H3. BRD9539 inhibits EHMT2 with an IC₅₀ of 6.3 μM. It also inhibits methyl transferase PRC2 with a similar IC₅₀...

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  • 2,4-Pyridinedicarboxylic Acid

    Biovision | 2,4-Pyridinedicarboxylic Acid | B2809

    2,4-Pyridinedicarboxylic Acid is an inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases. It structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus inhibiting a range of enzymes. As a 2-OG mimic it also inhibits prolyl,...

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  • PRMT4/CARM1 Inhibitor

    Biovision | PRMT4/CARM1 Inhibitor | B2808

    PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM. In human prostate adenocarcinoma cancer LNCaP cells,...

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  • Delphinidin (chloride)

    Biovision | Delphinidin (chloride) | B2807

    Delphinidin is a natural plant pigment. It serves as the precursor of certain anthocyanins. It is used as an anthocyanin standard.The pigment is found in grapes, cranberries, and some flowers. It is an antioxidant. It shows multiple effects. It causes...

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  • CAY10669

    Biovision | CAY10669 | B2806

    CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor). The IC₅₀ for inhibition of PCAF is 662 μM. CAY10669 at 30-60 μM concentration dose-dependently inhibits histone H4 acetylation in HepG2 cells...

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  • Coumarin-SAHA

    Biovision | Coumarin-SAHA | B2805

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin...

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  • JGB1741

    Biovision | JGB1741 | B2804

    JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231...

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  • F-Amidine (trifluoroacetate salt)

    Biovision | F-Amidine (trifluoroacetate salt) | B2803

    F-Amidine (trifluoroacetate salt) is an irreversible inhibitor of protein arginine deiminase (PAD). The in vitro IC₅₀ values are 29.5 µM, 350 µM, and 21.6 µM for PAD1, PAD3 and PAD4, respectively. The IC₅₀ for cytoxicity in HL-60, MCF-7, and HT-29 cancer...

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  • Cl-Amidine (hydrochloride)

    Biovision | Cl-Amidine (hydrochloride) | B2802

    Cl-Amidine (hydrochloride) is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor. It catalyzes the post-translational modification of arginine residues on histones to form citrulline. The in vitro IC₅₀ values are 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6...

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  • Sulforaphane

    Biovision | Sulforaphane | B2801

    Sulforaphane is an isothiocyanate found in cruciferous vegetables such as broccoli. It has anti-cancer activity and targets multiple pathways in cancer development. It induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene...

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  • 4-Iodo-SAHA

    Biovision | 4-Iodo-SAHA | B2800

    4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay, similar to that of SAHA. 4-iodo-SAHA...

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  • DFHBI-1T

    Biovision | DFHBI-1T | B2799

    DFHBI-1T is a mimic of green fluorescent protein (GFP) fluorophore for imaging RNA in living cells. Fluorescence is activated by binding to Spinach2 or Broccoli aptamers. Displays peak excitation maxima of 482 nm and peak fluorescence emission of 505 nm...

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  • BI

    Biovision | BI | B2798

    BI is a derivative of DFHBI (Cat. No. B2797) that binds Broccoli™ with higher affinity and deliver improved cellular fluorescence. In cells, BI has been found to stabilize the Broccoli™ structure and promote its folding. Additionally, Broccoli™/BI...

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  • DFHBI

    Biovision | DFHBI | B2797

    DFHBI is a cell-permeable non-fluorescent small molecule derived from the GFP chromophore. Upon binding to the “Spinach™” aptamer, DFHBI is converted to a highly fluorescent state that can be detected at the emission wavelength of 501 nm. DFHBI displays...

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  • Zalcitabine

    Biovision | Zalcitabine | B2796

    Zalcitabine is an antiviral pyrimidine nucleoside analog effective against HIV replication. In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV reverse transcriptase (Ki = 51 nM). It incorporates into...

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  • Sotrastaurin

    Biovision | Sotrastaurin | B2795

    Sotrastaurin (AEB071) is a potent pan-PKC (Protein Kinase C) inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.Sotrastaurin (AEB071) is a potent pan-PKC (Protein Kinase C)...

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  • Biochanin A

    Biovision | Biochanin A | B2794

    Biochanin A is an isoflavone phytoestrogen found in red clover that acts as a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. Biochanin A is also a ligand for the aryl hydrocarbon receptor (AhR)...

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  • CAY-10499

    Biovision | CAY-10499 | B2793

    CAY-10499 is a potent non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively).CAY-10499 is a potent non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL,...

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  • Tectorigenin

    Biovision | Tectorigenin | B2792

    Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants. It has been reported to display a variety of biological activities including antitumor and antibacterial effects, free radical neutralization, and selective estrogen receptor...

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  • BMS-935177

    Biovision | BMS-935177 | B2791

    BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and...

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  • ARQ-531

    Biovision | ARQ-531 | B2790

    ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with...

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  • Orelabrutinib (ICP-022)

    Biovision | Orelabrutinib (ICP-022) | B2789

    Orelabrutinib is a potent and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of...

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  • PCI-29732

    Biovision | PCI-29732 | B2788

    PCI-29732 is a selective and irreversible BTK (Bruton’s tyrosine kinase) inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.PCI-29732 is a selective...

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  • Adaphostin

    Biovision | Adaphostin | B2787

    Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM) that displays anti-proliferative activity in leukemia models, human prostate cancer cell line PC-3 and other cancer cell lines. Adaphostin is a potent inducer of myeloid cell death...

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