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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • HDAC1&2 Inhibitor

    Biovision | HDAC1&2 Inhibitor | B2930

    HDAC1&2 inhibitor selectively inhibits Histone deacetylases HDAC1 and HDAC2 with an IC₅₀ of 10 nM and 105 nM for HDAC1 and HDAC2 respectively. It shows a GI₅₀ of 100 nM for HCT-116 cells.HDAC1&2 inhibitor selectively inhibits Histone deacetylases HDAC1...

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  • CINK4

    Biovision | CINK4 | B2929

    CINK4 is a triaminopyrimidine derivative that inhibits Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC₅₀ values of 1.5 and 5.6 μM, respectively. It reduces retinoblastoma protein phosphorylation at Ser780 and Ser795 and induces cell cycle arrest in...

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  • Cdk4 Inhibitor

    Biovision | Cdk4 Inhibitor | B2928

    Cdk4 Inhibitor is an indolocarbazole which is a potent, selective and ATP competitive cyclin D1/CDK4 inhibitor. It has an IC₅₀ value of 76 nM. It inhibits tumor cell growth, arrests tumor cells at the G1 phase, and inhibits pRb phosphorylation in HCT-116...

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  • TCS 21311

    Biovision | TCS 21311 | B2927

    TCS 21311 is a potent JAK3 (Janus kinase 3) inhibitor. It shows high selectivity for JAK3 over JAK1, JAK2 and TYK2 with IC₅₀ values of 8 nM, 1017 nM, 2550 nM and 8055 nM respectively. It also inhibits GSK-3β, PKCα and PKCθ with IC₅₀ values of 3 nM, 13 nM...

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  • K-604, ACAT-1 Inhibitor

    Biovision | K-604, ACAT-1 Inhibitor | B2926

    K-604 is an inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1). The IC₅₀ values of K-604 for human ACAT-1 and ACAT-2 are 0.45 μM and 102.85 μM respectively, showing that K-604 is 229-fold more selective for ACAT-1. It suppresses the development...

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  • VUF 8430 dihydrobromide

    Biovision | VUF 8430 dihydrobromide | B2925

    VUF 8430 is a high affinity agonist (pKi = 7.5) for the histamine H4 receptor (pEC₅₀= 7.3). It is a moderate affinity agonist for the H3 receptor and is inactive at H1 and H2 receptor.VUF 8430 is a high affinity agonist (pKi = 7.5) for the histamine H4...

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  • Nek2/Hec1 inhibitor

    Biovision | Nek2/Hec1 inhibitor | B2924

    Nek2/Hec1 inhibitor targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death. The IC₅₀ for cytotoxicity in MDA-MB231, MDA-MB468, HeLa and K562 cell lines is 1.1 μM, 3.4 μM,1.6 μM and 1.2 μM respectively.Nek2/Hec1 inhibitor...

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  • SU 3327

    Biovision | SU 3327 | B2923

    SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of...

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  • cFMS Receptor Inhibitor IV

    Biovision | cFMS Receptor Inhibitor IV | B2922

    cFMS Receptor Inhibitor IV is a furan carboxamide compound that is a potent, reversible, and ATP-competitive inhibitor of cFMS (Colony-stimulating Factor-1 Receptor) Tyrosine Kinase. It blocks cFMS autophosphorylation in CSF-1/M-CSF-stimulated HEK-293...

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  • Bifeprunox

    Biovision | Bifeprunox | B2921

    Bifeprunox shows positive effects in treating psychotic symptoms in schizophrenia. It is a third-generation antipsychotic agent which acts as a partial agonist at dopamine D2 receptors and is an efficacious agonist at serotonin 5-HT1A receptors. It shows...

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  • CK2 inhibitor

    Biovision | CK2 inhibitor | B2920

    CK2 inhibitor is a 3-carboxy-4(1H)-quinolone which selectively inhibits casein kinase 2 (CK2) with an IC₅₀ value of 0.3 μM. It competitively inhibits binding of ATP with a Ki value of 0.06 µM.CK2 inhibitor is a 3-carboxy-4(1H)-quinolone which selectively...

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  • MAO-A/MAO-B Inhibitor

    Biovision | MAO-A/MAO-B Inhibitor | B2919

    MAO-A/MAO-B inhibitor is a coumarin derivative which inhibits monoamine oxidases MAO-A and MAO-B with an IC₅₀ of 235 ± 18.52 nM and 165 ± 7.04 nΜ, respectively.MAO-A/MAO-B inhibitor is a coumarin derivative which inhibits monoamine oxidases MAO-A and...

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  • Syk Inhibitor II

    Biovision | Syk Inhibitor II | B2918

    Syk Inhibitor II is an ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 41 nM. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk. It prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro and inhibits...

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  • TGX-155

    Biovision | TGX-155 | B2917

    TGX-155 is an inhibitor of phosphoinositide 3-kinase (PI3K). PI3Ks and their lipid product phosphatidylinositol-3,4,5-trisphosphate are involved in signaling events in many cellular processes. TGX-155 selectively inhibits the p110β catalytic subunit of...

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  • BX-320

    Biovision | BX-320 | B2916

    BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and angiogenesis. BX-320 inhibits PDK1 enzyme activity in a kinase...

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  • ZM306416

    Biovision | ZM306416 | B2915

    ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM, respectively. It is also a potent inhibitor of EGFR with an IC₅₀...

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  • CAY10602

    Biovision | CAY10602 | B2914

    CAY10602 is an activator of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. SIRT1 alters gene expression by deacetylating transcription factors such as NF-κB, p53, and FOXO. CAY10602 suppresses the NF-κB-dependent induction of TNF-α...

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  • R112

    Biovision | R112 | B2913

    R112 is an inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 226 nM in cultured human mast cells. It is an ATP-competitive Syk inhibitor with a Ki of 96 nM. It completely and rapidly inhibits all mast cell activation cascades triggered by IgE...

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  • CAY10575

    Biovision | CAY10575 | B2912

    CAY10575 is an inhibitor of IKK-ε. IKK-ε is a homolog of IKK-α and IKK-β which can activate NF-κB. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC₅₀...

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  • NSC109116

    Biovision | NSC109116 | B2911

    NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone. NSC109116 is a salicylic compound that selectively inhibits...

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  • NSC 210902

    Biovision | NSC 210902 | B2910

    NSC 210902 inhibits casein kinase 2 (CK2) with an IC₅₀ value of 1 μM. It competitively inhibits binding of ATP with a Ki value of 0.28 µM. It minimally inhibits protein kinases JNK3, GSK3, Cdk5, MSK1 and displays selectivity for CK2.NSC 210902 inhibits...

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  • NH125

    Biovision | NH125 | B2909

    NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. It inhibits histidine protein kinase YycG with an IC₅₀ of 6.6 µM. It selectively inhibits eEF-2 kinase activity with an IC₅₀ of 60 nM in vitro and weakly inhibits...

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  • WHI-P180

    Biovision | WHI-P180 | B2908

    WHI-P180 is a multi-kinase inhibitor. It inhibits human proto-oncogene receptor tyrosine kinase RET (Rearranged during Transfection) and kinase insert domain receptor (KDR) with IC₅₀ values of 4.5 nM and 66 nM respectively. It inhibits epidermal growth...

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  • INH6

    Biovision | INH6 | B2907

    INH6 is a potent inhibitor of Hec1/Nek2 which regulate the mitotic spindle formation together. It causes chromosome mis-alignment, apoptosis and cell death. It inhibits proliferation of MDA-MB231, MDA-MB468, HeLa and K562 cells with IC₅₀ values of 1.7...

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  • Daidzein

    Biovision | Daidzein | B2906

    Daidzein is an isoflavone phytoestrogen found in soybean, with antioxidant properties. It increases transactivation of estrogen receptor β-induced transcription. It binds to estrogen receptor β (ER-β; Ki = 2.8 µM) but not ER-α at concentrations up to 1...

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  • GW1100

    Biovision | GW1100 | B2905

    GW1100 is an antagonist for the free fatty acid receptor FFAR1 (GPR40). It inhibits GPR40-mediated Ca2+ elevations stimulated by GW 9508 (agonist for GPR40 and GPR120) and linoleic acid with pIC₅₀ values of 5.99 ± 0.03 and 5.99 ± 0.06 respectively...

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  • CAY10577

    Biovision | CAY10577 | B2904

    CAY10577 is an inhibitor of Casein kinase 2 (CK2) with an IC₅₀ value of 0.8 µM. CK2 is a serine/threonine-selective protein kinase which is implicated in the development of some cancers, viral infections and inflammatory failures.CAY10577 is an inhibitor...

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  • Cdk9 Inhibitor II

    Biovision | Cdk9 Inhibitor II | B2903

    Cdk9 Inhibitor II is a potent and selective inhibitor of Cdk9 with an IC₅₀ value of 0.35 µM in vitro. It is also an inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC₅₀ values of 13.3 µM and 20 µM respectively. It reduces the frequency of...

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  • Arcyriaflavin A

    Biovision | Arcyriaflavin A | B2902

    Arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK4) with an IC₅₀ of 140 nM. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC₅₀ of 25 nM. It inhibits the replication of human cytomegalovirus (HCMV) in vitro, with an...

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  • 4EGI-1

    Biovision | 4EGI-1 | B2901

    4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11 μM. It inhibits proliferation of human cancer cells. It...

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  • RTA 408

    Biovision | RTA 408 | B2860

    RTA 408 is a synthetic oleanane triterpenoid that activates Nrf2. RTA 408 activates Nrf2 and suppresses nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7 macrophage cells at low concentrations (≤ 25 nM). It inhibits...

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  • L002

    Biovision | L002 | B2859

    L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those...

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  • YW3-56 (hydrochloride)

    Biovision | YW3-56 (hydrochloride) | B2858

    YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 which convert protein arginine residues to citrulline. The IC₅₀ for inhibition of PAD4 and PAD2 is about 1–2 μM and 0.5–1 μM respectively. YW3-56 inhibits the growth of osteosarcoma U2OS...

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  • I-BRD9

    Biovision | I-BRD9 | B2857

    I-BRD9 is an inhibitor and chemical probe for BRD9 bromodomain. BRD9 (bromodomain-containing protein 9) is a part of the chromatin remodeling SWI/SNF BAF complex. Bromodomain "reader" modules recognize the acetylation of histone lysine residues. I-BRD9...

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  • TC-E 5002

    Biovision | TC-E 5002 | B2856

    TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7. It potently inhibits KDM2A, KDM7A and KDM7B with an IC₅₀ of 6.8 μM, 0.2 μM and 1.2 μM respectively. It inhibits the growth of KYSE150 and HeLa cells with GI₅₀ values of...

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  • Tasquinimod

    Biovision | Tasquinimod | B2855

    Tasquinimod has anti-angiogenic, antitumor and immune-modulatory properties. It shows consistent anti-angiogenic activity in vitro at doses between 10-50 μM. The mechanism of action of tasquinimod is not clear but may involve inhibition of MDSC action, a...

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  • NI-57

    Biovision | NI-57 | B2854

    NI-57 is an inhibitor of the bromodomains of BRPF proteins. The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment and activation of MOZ/MORF histone acetyltransferases to chromatin...

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  • LP99

    Biovision | LP99 | B2853

    LP99 is an inhibitor of BRD9 and BRD7 bromodomains. LP99 inhibits the interactions of both BRD7 and BRD9 with histones H3.3 and H4, with IC₅₀ values in the low micromolar range in bioluminescence resonance energy transfer (BRET) assays in HEK293 cells...

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  • Resminostat (hydrochloride)

    Biovision | Resminostat (hydrochloride) | B2852

    Resminostat is a potent inhibitor of histone deacetylases (HDAC) 1, 3 and 6 with IC₅₀ ranging from 43–72 nM. It induces hyperacetylation of histone H4, abrogates cell growth and induces apoptosis in multiple myeloma cells with an IC₅₀ of 2.5-3 µM. It...

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  • MS37452

    Biovision | MS37452 | B2851

    MS37452 is a competitive inhibitor of CBX7 (Chromobox homolog 7) chromodomain binding to trimethylated lysine 27 of histone 3 (H3K27me3). It inhibits CBX7-H3K27me3 binding with a Ki of 43.0 μM. At 250 µM, it derepresses transcription of Polycomb...

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  • XY1

    Biovision | XY1 | B2850

    XY1 is an inactive control of SGC707. SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM. XY1 is an...

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  • VLX600

    Biovision | VLX600 | B2849

    VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic activity under conditions of nutrient starvation. It...

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  • UMB-32

    Biovision | UMB-32 | B2848

    UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent lines. UMB-32 binds to TAF1 and TAF1L with the Kd...

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  • BB-Cl-Amidine

    Biovision | BB-Cl-Amidine | B2847

    BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative of the PAD inhibitor Cl-amidine in which the C-terminal...

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  • SGC707

    Biovision | SGC707 | B2846

    SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a concentration of 1 µM.SGC707 is a potent, selective and...

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  • p-nitro-Pifithrin-α

    Biovision | p-nitro-Pifithrin-α | B2845

    p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. Pifithrin-α is an inhibitor of p53 that blocks p53-dependent apoptosis. p-nitro-Pifithrin-α blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons more potently than...

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  • Acetyl Coenzyme A (sodium salt)

    Biovision | Acetyl Coenzyme A (sodium salt) | B2844

    Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic reactions. It is formed either by the oxidative decarboxylation of pyruvate, β-oxidation of fatty acids or oxidative degradation of certain amino acids. It is an intermediate in...

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  • AGK7

    Biovision | AGK7 | B2843

    AGK7 is an inactive control and an isomer of AGK2. AGK2 is a cell-permeable, selective inhibitor of SIRT2 which is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase (IC₅₀ = 3.5 µM). AGK2 rescues α-synuclein toxicity in α-Syn-H4 cells while...

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  • CAY10685

    Biovision | CAY10685 | B2842

    CAY10685 is an active clickable analog of the lysine acetyltransferase inhibitor 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (CPTH2 hydrochloride). The alkyne moiety reacts with an azide group upon copper exposure which tags the...

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  • GSK-J5 (hydrochloride)

    Biovision | GSK-J5 (hydrochloride) | B2841

    GSK-J5 is an isomer of GSK-J4 and a prodrug for negative control GSK-J2. GSK-J2 is a negative control for GSK-J1, which is an inhibitor of the H3K27 histone demethylases JMJD3 and UTX. GSK-J5 did not have any effect on TNF-α protein production that...

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  • SAHA-Bpyne

    Biovision | SAHA-Bpyne | B2840

    SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native proteomes and live cells. It labels HDAC complex proteins in...

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  • Indole-3-carbinol

    Biovision | Indole-3-carbinol | B2839

    Indole-3-carbinol is an anticancer phytochemical in cruciferous vegetables. It is produced by the breakdown of the glucosinolate glucobrassicin by the action of enzyme myrosinase. It induces apoptosis in cancer cells. It inhibits NF-κB, Akt and MAPK...

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