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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • Tafamidis

    Biovision | Tafamidis | B3035

    Tafamidis is a potent kinetic stabilizer of transthyretin (TTR). Tafamidis binds selectively and with negative cooperativity (Kd values ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer and kinetically stabilizes...

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  • Lasmiditan hemisuccinate

    Biovision | Lasmiditan hemisuccinate | B3032

    Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan (3 mg/kg) inhibited markers associated with electrical...

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  • GBT-440

    Biovision | GBT-440 | B3031

    GTB-440 is a modulator of sickle hemoglobin S (HbS). It binds to the N‐terminal valine of one of the haemoglobin α chains and increases HbS affinity for oxygen. GBT440 dose‐dependently increases HbS affinity for oxygen (EC₅₀ = 8·2 μM) for purified HbS...

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  • Semaglutide acetate

    Biovision | Semaglutide acetate | B3030

    Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R). It is a glucagon-like peptide-1 (GLP-1) analogue approved for the treatment of type 2 diabetes mellitus. It has two amino acid substitutions compared to human GLP-1 (Aib(8), Arg(34))...

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  • Nidufexor

    Biovision | Nidufexor | B3029

    Nidufexor is an agonist of Farnesoid X receptor (FXR). Administration of Nidufexor (10 and 30 mg/kg for 3 weeks) modulates FXR-dependent genes in vivo leading to the reduction of steatosis, inflammation, and fibrosis in a murine NASH model. It is in...

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  • Licogliflozin

    Biovision | Licogliflozin | B3028

    Licogliflozin is a dual inhibitor of Sodium/glucose cotransporters SGLT1 and SGLT2 with a higher selectivity for SGLT2 (in vitro IC₅₀ values of 20.6 and 0.58 nM, respectively). It causes a reduction in body weight from baseline versus placebo after 24...

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  • Aramchol

    Biovision | Aramchol | B3027

    Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model...

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  • Cenicriviroc

    Biovision | Cenicriviroc | B3026

    Cenicriviroc is a potent inhibitor of C-C chemokine receptors CCR5 and CCR2. It is an orally bioavailable derivative of TAK-779 with potent anti-HIV-1 activity. It blocks the binding of MIP-1α and MIP-1β to CCR5 with an IC₅₀ of 2.3 nM. It inhibits the...

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  • Tucatinib

    Biovision | Tucatinib | B3025

    Tucatinib is an oral, potent, selective and ATP-competitive small-molecule inhibitor of Receptor tyrosine-protein kinase ErbB2 (also called HER2 or human epidermal growth factor receptor 2) with an IC₅₀ of 14 nM against ErbB2 enzyme. It inhibits the...

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  • Ertapenem sodium

    Biovision | Ertapenem sodium | B3024

    Ertapenem is a carbapenem broad spectrum antibiotic effective against Gram-positive and Gram-negative bacteria. It binds to the penicillin binding proteins (PBPs) and has high affinity for PBPs 2 and 3. It shows MIC₉₀ values

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  • Netilmicin Sulfate

    Biovision | Netilmicin Sulfate | B3023

    Netilimicin is an aminoglycoside antibiotic. It is active against S. aureus, N. gonorrhoeae, E. coli, P. mirabilis, and P. aeruginosa (MIC values = 0.4, 3.1, 0.8, 1.6, and 0.4 µg/ml, respectively) as well as Enterococci, Enterobacter, Citrobacter, and...

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  • Maduramicin Ammonium

    Biovision | Maduramicin Ammonium | B3022

    Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is commonly used in veterinary medicine as an anti-coccidial agent. It is cytotoxic against Cryptosporidium parvum infection in Swiss mice...

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  • Famotidine

    Biovision | Famotidine | B3021

    Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses...

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  • Narasin

    Biovision | Narasin | B3020

    Narasin is an ionophore antibiotic which is a derivative of salinomycin. It modifies the permeability of cellular membranes to cationic metal species. It inhibits NF-κB signaling via inhibition of IκBα phosphorylation with an IC₅₀ of 3.2 µM. Treatment...

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  • AMG-517

    Biovision | AMG-517 | B3019

    AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC₅₀ of 0.9 nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when administered intrathecally at a dose of 165 µg. It (150 and 300...

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  • LM22B-10

    Biovision | LM22B-10 | B3018

    LM22B-10 is an activator of Tropomyosin-receptor kinase neurotrophin receptors TrkB and TrkC. It binds to TrkB and TrkC in a dose-dependent manner at concentrations of 250 nM-2000 nM. It increases cell survival and accelerates neurite outgrowth. LM22B-10...

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  • Ro 08-2750

    Biovision | Ro 08-2750 | B3017

    Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor p75(NTR). It inhibits NGF-induced cell death of SK-N-MC...

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  • ML-193

    Biovision | ML-193 | B3016

    ML-193 is a selective quinoline aryl sulfonamide antagonist for GPR55, a lysophosphatidylinositol (LPI)-sensitive receptor that is also involved in cannabinoid signaling. It inhibits GPR55 with an IC₅₀ of 221 nM. It also inhibits GPR55-dependent ERK...

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  • Baloxavir marboxil

    Biovision | Baloxavir marboxil | B3014

    Baloxavir marboxil is a prodrug that is metabolised to the active form baloxavir acid also known as S‐033447. S‐033447 is a small molecule inhibitor of the cap‐dependent endonuclease of influenza A and B viruses. It has shown nanomolar antiviral activity...

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  • Istradefylline

    Biovision | Istradefylline | B3013

    Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing dyskinesias or hyperactivity in an MPTP-induced...

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  • WIN 55,212-2 Mesylate

    Biovision | WIN 55,212-2 Mesylate | B3012

    (+)-WIN 55,212-2 (mesylate) is a potent aminoalkyl indole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. It shows antihyperalgesic and anti-inflammatory properties. It (0...

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  • (S)-(-)-Bay K 8644

    Biovision | (S)-(-)-Bay K 8644 | B3011

    (S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar concentrations in guinea-pig ventricular myocytes. The...

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  • MGL-3196

    Biovision | MGL-3196 | B3010

    A selective thyroid hormone receptor β agonist with EC₅₀ values of 0.21 and 3.74 µM for THRβ and THRα, respectively. It significantly lowers non-HDL-C and liver TG in hypercholesterolemic rat and rabbit models at doses where there is no effect on TSH...

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  • Alofanib

    Biovision | Alofanib | B3009

    Alofanib is a novel selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase. It inhibits phosphorylation of FGF receptor substrate 2α (FRS2α) with IC₅₀ values of 7 nM and 9 nM in cancer cells expressing different...

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  • Roblitinib

    Biovision | Roblitinib | B3008

    Roblitinib is a reversible-covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) tyrosine kinase. It shows 1000-fold selectivity for FGFR4 over FGFR1/2/3 and other kinases, with an IC₅₀ value of 1.9 nM against FGFR4. It shows potent antitumor...

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  • Merestinib

    Biovision | Merestinib | B3007

    Merestinib is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM. It shows more anti-proliferative activity in cell lines with MET gene amplification (MKN45, Hs746T and H1993) than cell lines...

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  • Savolitinib

    Biovision | Savolitinib | B3006

    Savolitinib is an inhibitor of cMET tyrosine kinase or hepatocyte growth factor receptor (HGFR). It potently inhibits the tyrosine kinase activity of recombinant cMET in vitro with an IC₅₀ value of 4 nM. It inhibits proliferation of cell lines SNU‐5,...

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  • Capmatinib

    Biovision | Capmatinib | B3005

    Capmatinib is an ATP competitive inhibitor of c-MET kinase or hepatocyte growth factor receptor (HGFR). Binding of Hepatocyt Growth Factor to c-MET receptor causes activation of multiple downstream pathways. Capmatinib potently inhibits in vitro kinase...

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  • Theliatinib

    Biovision | Theliatinib | B3004

    Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05 nM and IC₅₀ of 3 nM. It exhibits strong antitumor activity in patient-derived estrogen cancer xenograft (PDECX) models with high EGFR...

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  • Icotinib

    Biovision | Icotinib | B3003

    Icotininb is a potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC₅₀ of 5 nM. It blocks EGFR-mediated intracellular tyrosine phosphorylation IC₅₀ of 45 nM in the human epidermoid carcinoma A431 cell line and inhibits...

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  • Allitinib

    Biovision | Allitinib | B3002

    Allitinib is a novel anilino-quinazoline compound that inhibits ErbB tyrosine kinases: epidermal growth factor receptor (EGFR) and ErbB2. It inhibits EGFR and ErbB2 with IC₅₀ values of 0.5 nM and 3 nM in cell-free assays. It inhibits the phosphorylation...

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  • Avapritinib

    Biovision | Avapritinib | B2999

    Avapritinib is an inhibitor of oncogenic KIT and PDGFRA mutations. The KIT receptor belongs to the class III receptor tyrosine kinase (RTK) family. Avapritinib potently inhibits the activation loop mutants KIT D816V and PDGFRA D842V and also inhibits...

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  • Branebrutinib

    Biovision | Branebrutinib | B2998

    Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. Branebrutinib...

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  • Remdesivir

    Biovision | Remdesivir | B2997

    Remdesivir is a nucleoside analogue with antiviral activity. It inhibits Middle East respiratory syndrome coronavirus (MERS-CoV)- or severe acute respiratory syndrome coronavirus (SARS-CoV)-infected HAE cultures with EC₅₀ values of 74 nM and 69 nM. It...

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  • Selpercatinib

    Biovision | Selpercatinib | B2996

    Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven lung tumours with enhanced clinical activity and better...

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  • Avitinib

    Biovision | Avitinib | B2995

    Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase. It inhibits EGFR L858R/T790M double mutations with an IC₅₀ value of 0.18 nM which is nearly 43-fold potent over...

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  • (-)-Quinpirole hydrochloride

    Biovision | (-)-Quinpirole hydrochloride | B2994

    Quinpirole is a dopamine D2 receptor agonist with Ki values of 4.8 nM, 24 nM, 30nM and 1900 nM at D2, D3, D4 and D1 receptors respectively. Quinpirole inhibits single pulse dopamine overflow in a concentration-dependent manner with an IC₅₀ of 32.5 nM...

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  • Cetirizine dihydrochloride

    Biovision | Cetirizine dihydrochloride | B2993

    Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts anti-inflammatory effects apart from H1 antagonism. It...

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  • 2-Arachidonoylglycerol

    Biovision | 2-Arachidonoylglycerol | B2992

    2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid G-protein coupled receptors (CB1 and CB2) with Ki values of 472 nM and 1400 nM respectively. 2-arachidonoylglycerol induces a rapid, transient increase in...

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  • CMPD-1

    Biovision | CMPD-1 | B2991

    MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a K(i)(app) of 330 nM. It does not inhibit the...

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  • Guanfacine hydrochloride

    Biovision | Guanfacine hydrochloride | B2990

    Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with anti-hypertensive activity. It shows Ki values of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay. Guanfacine (0.3-5 mg/kg) binds to adrenergic...

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  • Poly(I:C)

    Biovision | Poly(I:C) | B2989

    Poly(I:C) is a double-stranded homopolymer of polyinosinic acid and polycytidylic acid. Transfection of Poly(I:C) (1 μg/ml) into NIT 1 cells has been used as a model of intracellular double-stranded RNA-induced beta-cell apoptosis. Poly(I:C) induced...

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  • 27-Hydroxycholesterol

    Biovision | 27-Hydroxycholesterol | B2988

    27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and 71 nM, respectively, and is a potent suppressor of...

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  • Desipramine hydrochloride

    Biovision | Desipramine hydrochloride | B2987

    Desipramine HCl is a tricyclic antidepressant that is a selective inhibitor of norepinephrine transporter with Ki values of 4 nM, 61 nM and 78.72 μM for Norepinephrine Transporter (NET), Serotonin Transporter (SERT) and Dopamine Transporter (DAT)...

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  • LDN-193189 dihydrochloride

    Biovision | LDN-193189 dihydrochloride | B2986

    LDN-193189 inhibits transcriptional activity of the (Bone Morphogenetic Protein) BMP type I receptors known as activin receptor-like kinases (ALKs). It inhibits ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on...

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  • Tasimelteon

    Biovision | Tasimelteon | B2985

    Tasimelteon is a potent Dual Melatonin Receptor Agonist (DMRA). It is used to treat non-24-hour sleep-wake disorder. The Ki values for binding affinity at melatonin receptors MT1 and MT2 receptor are 0.304 and 0.069 nM respectively in CHO–K1 cells. It...

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  • Ripasudil hydrochloride dihydrate

    Biovision | Ripasudil hydrochloride dihydrate | B2984

    Ripasudil (K-115) is a potent inhibitor of Rho kinase (ROCK), with IC₅₀ values of 19 and 51 nM for ROCK-2 and ROCK-1, respectively. Ripasudil (10 μM) induces cytoskeletal changes, including retraction, cell rounding and reduced actin bundles of cultured...

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  • Vigabatrin

    Biovision | Vigabatrin | B2983

    Vigabatrin (VGB) is a structural analogue of gamma-aminobutyric acid (GABA) that irreversibly inhibits GABA-transaminase (GABA-T). It inhibits the catabolism of GABA by GABA transaminase and increases GABA levels in the brain. Focal drug delivery into...

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